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Rabbit Anti-CNN2 Recombinant Antibody (EG748) (V2LY-1206-LY446)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG748
Antibody Isotype
IgG
Application
WB, IHC

Basic Information

Immunogen
Calponin protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calponin 2
Entrez Gene ID
1265
UniProt ID
Q99439
Function
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Biological Process
Actomyosin structure organization Source: InterPro
Cellular response to mechanical stimulus Source: MGI
Cytoskeleton organization Source: ProtInc
Interleukin-12-mediated signaling pathway Source: Reactome
Neutrophil degranulation Source: Reactome
Regulation of actin filament-based process Source: MGI
Cellular Location
Cytoskeleton; Stress fiber; Extracellular region; Cell-cell junction; Focal adhesion; Membrane; Specific granule lumen; Tertiary granule lumen
More Infomation

Jang, I., & Jin, J. P. (2022). Role of calponin 2 in cell migration and mechanoregulation. Biophysical Journal, 121(3), 266a.

Zhang, R., Li, S., Wang, Y., Cai, W., Liu, Q., & Zhang, J. (2021). Serum calponin 2 is a novel biomarker of tubal ectopic pregnancy. Fertility and Sterility, 116(4), 1020-1027.

Plazyo, O., Hao, W., & Jin, J. P. (2020). The absence of calponin 2 in rabbits suggests caution in choosing animal models. Frontiers in bioengineering and biotechnology, 8, 42.

Plazyo, O., Sheng, J. J., & Jin, J. P. (2019). Downregulation of calponin 2 contributes to the quiescence of lung macrophages. American Journal of Physiology-Cell Physiology, 317(4), C749-C761.

Feng, H. Z., Wang, H., Takahashi, K., & Jin, J. P. (2019). Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle. Journal of molecular and cellular cardiology, 129, 49-57.

Li, Y., Ding, X., Xiu, S., Du, G., & Liu, Y. (2019). LncRNA NEAT1 promotes proliferation, migration and invasion via regulating miR-296-5p/CNN2 axis in hepatocellular carcinoma cells. OncoTargets and therapy, 12, 9887.

Plazyo, O., Liu, R., Hossain, M. M., & Jin, J. P. (2018). Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE−/− mice. Journal of Molecular and Cellular Cardiology, 121, 233-241.

Kang, X., Wang, F., Lan, X., Li, X., Zheng, S., Lv, Z., ... & Zhou, S. (2018). Lentivirus-mediated shRNA targeting CNN2 inhibits hepatocarcinoma in vitro and in vivo. International journal of medical sciences, 15(1), 69.

Hu, J., Xie, W., Shang, L., Yang, X., Li, Q., Xu, M., ... & Wu, Y. (2017). Knockdown of calponin 2 suppressed cell growth in gastric cancer cells. Tumor Biology, 39(7), 1010428317706455.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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