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Mouse Anti-CP Recombinant Antibody (CBFYC-2130) (CBMAB-C2198-FY)

This product is mouse antibody that recognizes CP. The antibody CBFYC-2130 can be used for immunoassay techniques such as: ELISA, ICC, IHC, WB.
See all CP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2130
Application
ELISA, ICC, IHC, WB

Basic Information

Immunogen
Recombinant ceruloplasmin (Asp789-Gly1065) expressed in E. coli
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 50% glycerol
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ceruloplasmin
Introduction
CP (Ceruloplasmin) is a Protein Coding gene. Diseases associated with CP include Aceruloplasminemia and Wilson Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and copper ion binding. An important paralog of this gene is HEPHL1.
Entrez Gene ID
1356
UniProt ID
P00450
Alternative Names
Ceruloplasmin; Ceruloplasmin (Ferroxidase); Ferroxidase; EC 1.16.3.1; CP-2
Function
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
Biological Process
Cellular iron ion homeostasis Source: Reactome
Cellular protein metabolic process Source: Reactome
Copper ion transport Source: UniProtKB-KW
Iron ion homeostasis Source: GO_Central
Iron ion transport Source: GO_Central
Post-translational protein modification Source: Reactome
Cellular Location
Secreted. Colocalizes with GCP1 in secretory intracellular compartments.
Involvement in disease
Aceruloplasminemia (ACERULOP):
An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.

Kang, N. L., Zhang, J. M., Lin, M. X., Chen, X. D., Huang, Z. X., Zhu, Y. Y., ... & Zeng, D. W. (2020). Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients. World Journal of Gastroenterology, 26(27), 3952.

Vlasova, I. I., Sokolov, A. V., Kostevich, V. A., Mikhalchik, E. V., & Vasilyev, V. B. (2019). Myeloperoxidase-induced oxidation of albumin and ceruloplasmin: role of tyrosines. Biochemistry (Moscow), 84(6), 652-662.

Wang, B., & Wang, X. P. (2019). Does ceruloplasmin defend against neurodegenerative diseases?. Current Neuropharmacology, 17(6), 539-549.

Tian, S., Jones, S. M., Jose, A., & Solomon, E. I. (2019). Chloride control of the mechanism of human serum ceruloplasmin (Cp) catalysis. Journal of the American Chemical Society, 141(27), 10736-10743.

Rydén, L. (2018). Ceruloplasmin. In Copper proteins and copper enzymes (pp. 37-100). CRC Press.

Zhao, Y. S., Zhang, L. H., Yu, P. P., Gou, Y. J., Zhao, J., You, L. H., ... & Chang, Y. Z. (2018). Ceruloplasmin, a potential therapeutic agent for Alzheimer's disease. Antioxidants & redox signaling, 28(14), 1323-1337.

Zheng, J., Chen, M., Liu, G., Xu, E., & Chen, H. (2018). Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes. FEBS letters, 592(3), 394-401.

Golizeh, M., Lee, K., Ilchenko, S., Ösme, A., Bena, J., Sadygov, R. G., ... & Kasumov, T. (2017). Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes. Free Radical Biology and Medicine, 113, 461-469.

Squitti, R., Simonelli, I., Cassetta, E., Lupoi, D., Rongioletti, M., Ventriglia, M., & Siotto, M. (2017). Patients with increased non-ceruloplasmin copper appear a distinct sub-group of Alzheimer's disease: a neuroimaging study. Current Alzheimer Research, 14(12), 1318-1326.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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