Mouse Anti-CP Recombinant Antibody (CBYY-C0666) (CBMAB-C1975-YY)

Name: Mouse Anti-CP Recombinant Antibody (CBYY-C0666)
SKU: CBMAB-C1975-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-C0666

Application

WB, IHC-P

Immunogen

Ceruloplasmin Fusion Protein (194-446 aa).

Host Species

Mouse

Specificity

Human, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC-P	1:20-1:200
WB	1:1,000-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Ceruloplasmin

Entrez Gene ID

Human	1356
Rat	24268

UniProt ID

Human	P00450
Rat	P13635

Alternative Names

Cell Division Cycle 34; (E3-Independent) E2 Ubiquitin-Conjugating Enzyme R1; Ubiquitin-Conjugating Enzyme E2-CDC34; E2 Ubiquitin-Conjugating Enzyme R1; Ubiquitin-Protein Ligase R1; UBE2R1; UBCH3; Ubiquitin-Conjugating Enzyme E2-32 KDA Complementing; Ubiquitin-Conjugating Enzyme E2-32 KDa Complementing; Ubiquitin Conjugating Enzyme E2 R1;

Function

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).

Biological Process

Cellular iron ion homeostasis Source: Reactome
Cellular protein metabolic process Source: Reactome
Copper ion transport Source: UniProtKB-KW
Iron ion homeostasis Source: GO_Central
Iron ion transport Source: GO_Central
Post-translational protein modification Source: Reactome

Cellular Location

Secreted. Colocalizes with GCP1 in secretory intracellular compartments.

Involvement in disease

Aceruloplasminemia (ACERULOP):
An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.

Kang, N. L., Zhang, J. M., Lin, M. X., Chen, X. D., Huang, Z. X., Zhu, Y. Y., ... & Zeng, D. W. (2020). Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients. World Journal of Gastroenterology, 26(27), 3952.

Vlasova, I. I., Sokolov, A. V., Kostevich, V. A., Mikhalchik, E. V., & Vasilyev, V. B. (2019). Myeloperoxidase-induced oxidation of albumin and ceruloplasmin: role of tyrosines. Biochemistry (Moscow), 84(6), 652-662.

Wang, B., & Wang, X. P. (2019). Does ceruloplasmin defend against neurodegenerative diseases?. Current Neuropharmacology, 17(6), 539-549.

Tian, S., Jones, S. M., Jose, A., & Solomon, E. I. (2019). Chloride control of the mechanism of human serum ceruloplasmin (Cp) catalysis. Journal of the American Chemical Society, 141(27), 10736-10743.

Rydén, L. (2018). Ceruloplasmin. In Copper proteins and copper enzymes (pp. 37-100). CRC Press.

Zhao, Y. S., Zhang, L. H., Yu, P. P., Gou, Y. J., Zhao, J., You, L. H., ... & Chang, Y. Z. (2018). Ceruloplasmin, a potential therapeutic agent for Alzheimer's disease. Antioxidants & redox signaling, 28(14), 1323-1337.

Zheng, J., Chen, M., Liu, G., Xu, E., & Chen, H. (2018). Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes. FEBS letters, 592(3), 394-401.

Golizeh, M., Lee, K., Ilchenko, S., Ösme, A., Bena, J., Sadygov, R. G., ... & Kasumov, T. (2017). Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes. Free Radical Biology and Medicine, 113, 461-469.

Squitti, R., Simonelli, I., Cassetta, E., Lupoi, D., Rongioletti, M., Ventriglia, M., & Siotto, M. (2017). Patients with increased non-ceruloplasmin copper appear a distinct sub-group of Alzheimer's disease: a neuroimaging study. Current Alzheimer Research, 14(12), 1318-1326.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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