CP

CP (Ceruloplasmin) is a Protein Coding gene. Diseases associated with CP include Aceruloplasminemia and Wilson Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and copper ion binding. An important paralog of this gene is HEPHL1.
Full Name
Ceruloplasmin
Function
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
Biological Process
Cellular iron ion homeostasis Source: Reactome
Cellular protein metabolic process Source: Reactome
Copper ion transport Source: UniProtKB-KW
Iron ion homeostasis Source: GO_Central
Iron ion transport Source: GO_Central
Post-translational protein modification Source: Reactome
Cellular Location
Secreted. Colocalizes with GCP1 in secretory intracellular compartments.
Involvement in disease
Aceruloplasminemia (ACERULOP):
An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
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Anti-CP antibodies

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Mouse Anti-CP Recombinant Antibody (CBYY-C2046) (CBMAB-C3484-YY)

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Target: CP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C2046
Application*: WB, P
Datasheet SDS

Mouse Anti-CP Recombinant Antibody (CBYY-C2924) (V2LY-1206-LY891)

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Target: CP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2924
Application*: WB, P
Datasheet SDS

Mouse Anti-CP Recombinant Antibody (CBFYC-2129) (V2LY-1206-LY887)

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Target: CP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-2129
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-CP Recombinant Antibody (CP0359) (CBMAB-CP0359-LY)

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Target: CP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CP0359
Application*: WB
Datasheet SDS

Mouse Anti-CP Recombinant Antibody (CBYY-C0666) (CBMAB-C1975-YY)

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Target: CP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBYY-C0666
Application*: WB, P
Datasheet SDS

Mouse Anti-CP Recombinant Antibody (CBFYC-2130) (CBMAB-C2198-FY)

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Target: CP
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2130
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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