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CP

CP (Ceruloplasmin) is a Protein Coding gene. Diseases associated with CP include Aceruloplasminemia and Wilson Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and copper ion binding. An important paralog of this gene is HEPHL1.

Full Name

Ceruloplasmin

Function

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).

Biological Process

Cellular iron ion homeostasis Source: Reactome
Cellular protein metabolic process Source: Reactome
Copper ion transport Source: UniProtKB-KW
Iron ion homeostasis Source: GO_Central
Iron ion transport Source: GO_Central
Post-translational protein modification Source: Reactome

Cellular Location

Secreted. Colocalizes with GCP1 in secretory intracellular compartments.

Involvement in disease

Aceruloplasminemia (ACERULOP):
An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.

Anti-CP antibodies

Mouse Anti-CP Recombinant Antibody (CBYY-C2924) (CBMAB-C4367-YY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C2924

Application*: E, WB, IH

Mouse Anti-CP Recombinant Antibody (CBYY-C2046) (CBMAB-C3484-YY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C2046

Application*: E, IP, WB

Mouse Anti-CP Recombinant Antibody (CBYY-C0666) (CBMAB-C1975-YY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat, Human, Mouse

Clone: CBYY-C0666

Application*: WB, IF

Mouse Anti-CP Recombinant Antibody (CBFYC-2130) (CBMAB-C2198-FY)

SDS

Target: CP

Host: Mouse

Specificity: Human

Clone: CBFYC-2130

Application*: E, IC, IH, WB

Mouse Anti-CP Recombinant Antibody (CBFYC-2129) (CBMAB-C2197-FY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Rat

Clone: CBFYC-2129

Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-CP Recombinant Antibody (8/Ceruloplasmin) (CBMAB-C8919-LY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat, Human

Clone: 8/Ceruloplasmin

Application*: WB, IF

Mouse Anti-CP Recombinant Antibody (CAP554) (CBMAB-AP1653LY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CAP554

Application*: ICC, IHC, IP, WB

Mouse Anti-CP Recombinant Antibody (C1) (CBMAB-AP1652LY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: C1

Application*: ICC, IHC, IP, WB

Mouse Anti-CP Recombinant Antibody (11B) (CBMAB-AP1651LY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 11B

Application*: ELISA, IHC, WB

Mouse Anti-CP Recombinant Antibody (CF113) (CBMAB-FT373LY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Rat

Clone: CF113

Application*: ELISA, WB, IHC

Rabbit Anti-CP Recombinant Antibody (D7Q5W) (CBMAB-CP0359-LY)

SDS

Target: CP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D7Q5W

Application*: WB, IP

Mouse Anti-CP Recombinant Antibody (CBCNC-306) (CBMAB-C2729-CN)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBCNC-306

Application*: E, WB

Mouse Anti-CP Recombinant Antibody (CBCNC-305) (CBMAB-C2728-CN)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBCNC-305

Application*: E, WB

Mouse Anti-CP Recombinant Antibody (3C8A5) (CBMAB-C5837-LY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3C8A5

Application*: E, WB, IH

Mouse Anti-CP Recombinant Antibody (3B11) (CBMAB-C5687-LY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3B11

Application*: WB, IP, E

Mouse Anti-CP Recombinant Antibody (15j41) (CBMAB-C3294-LY)

SDS

Target: CP

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 15j41

Application*: E, IC, C, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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