Rat Cp ELISA Kit (V2LY-0626-LY3447)

Name: Rat Cp ELISA Kit
SKU: V2LY-0626-LY3447
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

2.43 U/L

Detection Range

5-1000 U/L

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Rat

Assay Type

Sandwich

Reactivity

Rat

Assay Time

1.5 h

Molecule Mass

120.8 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Ceruloplasmin

Function

Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu2+ ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).

Biological Process

Cellular iron ion homeostasis Source: Reactome
Cellular protein metabolic process Source: Reactome
Copper ion transport Source: UniProtKB-KW
Iron ion homeostasis Source: GO_Central
Iron ion transport Source: GO_Central
Post-translational protein modification Source: Reactome

Cellular Location

Secreted. Colocalizes with GCP1 in secretory intracellular compartments.

Involvement in disease

Aceruloplasminemia (ACERULOP):
An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.

Kang, N. L., Zhang, J. M., Lin, M. X., Chen, X. D., Huang, Z. X., Zhu, Y. Y., ... & Zeng, D. W. (2020). Serum ceruloplasmin can predict liver fibrosis in hepatitis B virus-infected patients. World Journal of Gastroenterology, 26(27), 3952.

Vlasova, I. I., Sokolov, A. V., Kostevich, V. A., Mikhalchik, E. V., & Vasilyev, V. B. (2019). Myeloperoxidase-induced oxidation of albumin and ceruloplasmin: role of tyrosines. Biochemistry (Moscow), 84(6), 652-662.

Wang, B., & Wang, X. P. (2019). Does ceruloplasmin defend against neurodegenerative diseases?. Current Neuropharmacology, 17(6), 539-549.

Tian, S., Jones, S. M., Jose, A., & Solomon, E. I. (2019). Chloride control of the mechanism of human serum ceruloplasmin (Cp) catalysis. Journal of the American Chemical Society, 141(27), 10736-10743.

Rydén, L. (2018). Ceruloplasmin. In Copper proteins and copper enzymes (pp. 37-100). CRC Press.

Zhao, Y. S., Zhang, L. H., Yu, P. P., Gou, Y. J., Zhao, J., You, L. H., ... & Chang, Y. Z. (2018). Ceruloplasmin, a potential therapeutic agent for Alzheimer's disease. Antioxidants & redox signaling, 28(14), 1323-1337.

Zheng, J., Chen, M., Liu, G., Xu, E., & Chen, H. (2018). Ablation of hephaestin and ceruloplasmin results in iron accumulation in adipocytes and type 2 diabetes. FEBS letters, 592(3), 394-401.

Golizeh, M., Lee, K., Ilchenko, S., Ösme, A., Bena, J., Sadygov, R. G., ... & Kasumov, T. (2017). Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes. Free Radical Biology and Medicine, 113, 461-469.

Squitti, R., Simonelli, I., Cassetta, E., Lupoi, D., Rongioletti, M., Ventriglia, M., & Siotto, M. (2017). Patients with increased non-ceruloplasmin copper appear a distinct sub-group of Alzheimer's disease: a neuroimaging study. Current Alzheimer Research, 14(12), 1318-1326.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human CP ELISA Kit (CAT#: V2LY-0626-LY1506)

Sheep CP ELISA Kit (CAT#: V2LY-0626-LY431)

Cattle CP ELISA Kit (CAT#: V2LY-0626-LY839)

Related Products

Mouse Anti-CP Recombinant Antibody (CBFYC-2130) (CAT#: CBMAB-C2198-FY)

Mouse Anti-CP Recombinant Antibody (CBYY-C0666) (CAT#: CBMAB-C1975-YY)

Mouse Anti-CP Recombinant Antibody (CBYY-C2924) (CAT#: V2LY-1206-LY891)

Sheep CP ELISA Kit (CAT#: V2LY-0626-LY431)

Human CP ELISA Kit (CAT#: V2LY-0626-LY1506)

Mouse Anti-CP Recombinant Antibody (CBYY-C2046) (CAT#: CBMAB-C3484-YY)

Cattle CP ELISA Kit (CAT#: V2LY-0626-LY839)

Mouse Anti-CP Recombinant Antibody (CBFYC-2129) (CAT#: V2LY-1206-LY887)

Rabbit Anti-CP Recombinant Antibody (CP0359) (CAT#: CBMAB-CP0359-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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