Rat Anti-CXCL14 Recombinant Antibody (C3436) (CBMAB-C3436-LY)

Name: Rat Anti-CXCL14 Recombinant Antibody (C3436)
SKU: CBMAB-C3436-LY
Rating: 5 (1 reviews)

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Published Data

Rat Anti-CXCL14 Recombinant Antibody (C3436) (CBMAB-C3436-LY) in IHC

H+E (100x, scale bar= 200 µm) and immunohistochemistry for CD68+ macrophages, p21, and CXCL14 (400x, scale bar=50 µm). For the p21 IHC the solid grey line represents the border of the area of necrosis, CV=central vein, showing that the p21+ hepatocytes border (red arrows) the necrotic area. ...View More

Umbaugh, D. S., Nguyen, N. T., Smith, S. H., Ramachandran, A., & Jaeschke, H. (2024). The p21+ perinecrotic hepatocytes produce the chemokine CXCL14 after a severe acetaminophen overdose promoting hepatocyte injury and delaying regeneration. Toxicology, 504, 153804. Distributed under Open Access license CC BY 4.0, without modification.

Rat Anti-CXCL14 Recombinant Antibody (C3436) (CBMAB-C3436-LY) in IHC

Immunohistochemistry of Cxcl14 in dermal fibrotic lesions of the paw in Tppp3-CreERT2/β-catenin ex3flox (left) and control mice (Tppp3-CreERT2/Rosa26-stop-tdTomato) (right). Samples were obtained 1 month after three tamoxifen injections of 1 mg. Marked Cxcl14 expression was detected in dermal fibrotic lesions (left). ...View More

Goto, A., Komura, S., Kato, K., Maki, R., Hirakawa, A., Tomita, H., ... & Akiyama, H. (2023). CXC domain ligand 14-mediated stromal cell-macrophage interaction as a therapeutic target for hand dermal fibrosis. Communications Biology, 6(1), 1173. Distributed under Open Access license CC BY 4.0, without modification.

Rat Anti-CXCL14 Recombinant Antibody (C3436) (CBMAB-C3436-LY) in IHC

Fluorescent immunohistochemistry was employed to visualize the distribution of Cxcl14 (green) and tdTomato (red) in the context of dermal fibrosis in the paw of Tppp3-CreERT2/Rosa26-stop-tdTomato/Rosa26-stop-rtTA/Col1a1::TetO-β-catenin mice (upper panel: Dox-off mice; lower panel: Dox-on mice). Dox-treated tdTomato-positive cells (β-catenin-expressing Tppp3-lineage cells) in the dermis co-expressed Cxcl14 (indicated by white arrowheads). The white square area is enlarged in the upper right panel. ...View More

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

C3436

Application

WB, IHC

Immunogen

Recombinant mouse CXCL14/BRAK, Ser23-Glu99.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1 μg/mL

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

More Infomation

Target

Full Name

C-X-C Motif Chemokine Ligand 14

Entrez Gene ID

57266

UniProt ID

Q9WUQ5

Function

Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Chemotaxis Source: ProtInc
Inner ear development Source: Ensembl
Killing of cells of other organism Source: UniProtKB
Negative regulation of myoblast differentiation Source: Ensembl
Positive regulation of natural killer cell chemotaxis Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

Ubiquitinated, followed by degradation by the proteasome.

Chen, L., Lei, Y., & Zhang, L. (2021). Role of CXC motif chemokine ligand 14 promoter region DNA methylation and single nucleotide polymorphism in influenza A severity. Respiratory Medicine, 185, 106462.

Matsushita, Y., Hasegawa, Y., Takebe, N., Onodera, K., Shozushima, M., Oda, T., ... & Ishigaki, Y. (2021). Serum C‐X‐C motif chemokine ligand 14 levels are associated with serum C‐peptide and fatty liver index in type 2 diabetes mellitus patients. Journal of Diabetes Investigation, 12(6), 1042-1049.

Wang, C., Zhao, N., Sato, F., Tanimoto, K., Okada, H., Liu, Y., & Bhawal, U. K. (2021). The roles of Y-box-binding protein (YB)-1 and CXC motif chemokine ligand 14 (CXCL14) in the progression of prostate cancer via extracellular-signal-regulated kinase (ERK) signaling. Bioengineered, 12(2), 9128-9139.

Cereijo, R., Quesada-Lopez, T., Gavalda-Navarro, A., Tarascó, J., Pellitero, S., Reyes, M., ... & Villarroya, F. (2021). The chemokine CXCL14 is negatively associated with obesity and concomitant type-2 diabetes in humans. International Journal of Obesity, 45(3), 706-710.

Qi, J., Li, J., Wang, Y., Wang, W., Zhu, Q., He, Y., ... & Sun, Y. (2021). Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients. Translational Research, 230, 55-67.

García-Beltran, C., Cereijo, R., Quesada-López, T., Malpique, R., López-Bermejo, A., de Zegher, F., ... & Villarroya, F. (2020). Reduced circulating levels of chemokine CXCL14 in adolescent girls with polycystic ovary syndrome: normalization after insulin sensitization. BMJ Open Diabetes Research and Care, 8(1), e001035.

Ko, H. M., Moon, J. S., Shim, H. K., Lee, S. Y., Kang, J. H., Kim, M. S., ... & Kim, S. H. (2020). Inhibitory effect of CXC motif chemokine ligand 14 on the osteogenic differentiation of human periodontal ligament cells through transforming growth factor-beta1. Archives of Oral Biology, 115, 104733.

Yang, X. Y., Ozawa, S., Kato, Y., Maehata, Y., Izukuri, K., Ikoma, T., ... & Hata, R. I. (2019). CXC motif chemokine ligand 14 is a unique multifunctional regulator of tumor progression. International Journal of Molecular Sciences, 20(8), 1872.

Li, L., Li, Q., Wei, L., Wang, Z., Ma, W., Liu, F., ... & Qian, Y. (2019). Chemokine (C‐X‐C motif) ligand 14 contributes to lipopolysaccharide‐induced fibrogenesis in mouse L929 fibroblasts via modulating PPM1A. Journal of Cellular Biochemistry, 120(8), 13372-13381.

Cereijo, R., Gavaldà-Navarro, A., Cairó, M., Quesada-López, T., Villarroya, J., Morón-Ros, S., ... & Villarroya, F. (2018). CXCL14, a brown adipokine that mediates brown-fat-to-macrophage communication in thermogenic adaptation. Cell metabolism, 28(5), 750-763.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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