Rabbit Anti-DCT Recombinant Antibody (EG935) (V2LY-0125-LY1234)

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Basic Information

Host Animal
Rabbit
Clone
EG935
Application
IHC-P
Immunogen
Recombinant protein of human TRP2.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC-P1:100-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA, Glycerol & PBS
Preservative
Sodium Azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Dopachrome Tautomerase
Entrez Gene ID
UniProt ID
Function
Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA).
Biological Process
Cell development Source: Ensembl
Developmental pigmentation Source: GO_Central
Epidermis development Source: ProtInc
Melanin biosynthetic process Source: Reactome
Melanin biosynthetic process from tyrosine Source: UniProtKB
Positive regulation of neuroblast proliferation Source: GO_Central
Response to blue light Source: UniProtKB
Ventricular zone neuroblast division Source: GO_Central
Cellular Location
Melanosome membrane; Melanosome. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Topology
Lumenal, melanosome: 24-472
Helical: 473-493
Cytoplasmic: 494-519
PTM
Glycosylated.

Volk, A. E., Hedergott, A., Preising, M., Rading, S., Fricke, J., Herkenrath, P., ... & Kubisch, C. (2021). Biallelic mutations in L-dopachrome tautomerase (DCT) cause infantile nystagmus and oculocutaneous albinism. Human Genetics, 140(8), 1157-1168.

Pennamen, P., Tingaud-Sequeira, A., Gazova, I., Keighren, M., McKie, L., Marlin, S., ... & Arveiler, B. (2021). Dopachrome tautomerase variants in patients with oculocutaneous albinism. Genetics in Medicine, 23(3), 479-487.

Rosani, U., Domeneghetti, S., Maso, L., Wegner, K. M., & Venier, P. (2019). An evolutionary perspective of dopachrome tautomerase enzymes in metazoans. Genes, 10(7), 495.

Salinas‑Santander, M., Trevino, V., de la Rosa‑Moreno, E., Verduzco‑Garza, B., Sánchez‑Domínguez, C. N., Cantú‑Salinas, C., ... & Ortiz‑López, R. (2018). CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients. Experimental and Therapeutic Medicine, 15(3), 2804-2811.

Dardente, H., & Lomet, D. (2018). Photoperiod and thyroid hormone regulate expression of l‐dopachrome tautomerase (Dct), a melanocyte stem‐cell marker, in tanycytes of the ovine hypothalamus. Journal of Neuroendocrinology, 30(9), e12640.

Sultana, H., Seo, D., Choi, N. R., Bhuiyan, M. S. A., Lee, S. H., Heo, K. N., & Lee, J. H. (2018). Identification of polymorphisms in MITF and DCT genes and their associations with plumage colors in Asian duck breeds. Asian-Australasian journal of animal sciences, 31(2), 180.

Aksoy, P., & Meneses, P. I. (2017). The role of DCT in HPV16 infection of HaCaTs. PLoS One, 12(1), e0170158.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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