Mouse Anti-DEF8 Recombinant Antibody (2H4) (CBMAB-D0667-YC)

Name: Mouse Anti-DEF8 Recombinant Antibody (2H4)
SKU: CBMAB-D0667-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2H4

Application

WB, FC

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Differentially Expressed In FDCP 8 Homolog

Introduction

DEF8 (Differentially Expressed In FDCP 8 Homolog) is a protein coding gene. And a paralog is PLEKHM1.

Entrez Gene ID

54849

UniProt ID

Q6ZN54

Alternative Names

Differentially Expressed In FDCP 8 Homolog; DEF-8; Differentially Expressed In FDCP 8 Homolog (Mouse);

Function

Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.

Biological Process

Intracellular signal transduction Source: InterPro
Lysosome localization Source: UniProtKB
Positive regulation of bone resorption Source: UniProtKB
Positive regulation of ruffle assembly Source: UniProtKB

Leyton, E., Matus, D., Espinoza, S., Benitez, J. M., Cortés, B. I., Gomez, W., ... & Nassif, M. (2021). DEF8 and autophagy-associated genes are altered in mild cognitive impairment, probable Alzheimer’s disease patients, and a transgenic model of the disease. Journal of Alzheimer's Disease, 82(s1), S163-S178.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DEF8 Recombinant Antibody (2H4) (CAT#: V2LY-0425-LY148)

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Mouse Anti-DEF8 Recombinant Antibody (4B6) (CAT#: V2LY-0425-LY149)

Mouse Anti-DEF8 Recombinant Antibody (2H4) (CAT#: V2LY-0425-LY148)

Mouse Anti-DEF8 Recombinant Antibody (4B6) (CAT#: CBMAB-D0668-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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