Rabbit Anti-DLGAP5 Recombinant Antibody (EG968) (CBMAB-EN1150-LY)

Name: Rabbit Anti-DLGAP5 Recombinant Antibody (EG968)
SKU: CBMAB-EN1150-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG968

Application

WB: 1:500~1:1000 ELISA: 1:40000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human DLGAP5.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

DLG Associated Protein 5

Introduction

DLGAP5 (DLG Associated Protein 5) is a Protein Coding gene. Among its related pathways are Aurora A signaling. Gene Ontology (GO) annotations related to this gene include phosphoprotein phosphatase activity. An important paralog of this gene is DLGAP1.

Entrez Gene ID

9787

UniProt ID

Q15398

Alternative Names

DLG Associated Protein 5; Discs Large Homolog Associated Protein 5; Disks Large-Associated Protein DLG7; Hepatoma Up-Regulated Protein; DAP-5; DLG7; HURP;

Function

Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.

Biological Process

Centrosome localization Source: GO_Central
Chromosome segregation Source: GO_Central
Kinetochore assembly Source: GO_Central
Mitotic chromosome movement towards spindle pole Source: UniProtKB
Mitotic spindle organization Source: GO_Central
Positive regulation of mitotic metaphase/anaphase transition Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Signaling Source: InterPro

Cellular Location

Spindle; Nucleus; Cytoplasm. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.

PTM

Ubiquitinated, leading to its degradation.
Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.

Mamoor, S. (2021). Over-expression of DLG associated protein 5 in human endometrial cancer.

Branchi, V., García, S. A., Radhakrishnan, P., Győrffy, B., Hissa, B., Schneider, M., ... & Schölch, S. (2019). Prognostic value of DLGAP5 in colorectal cancer. International Journal of Colorectal Disease, 34(8), 1455-1465.

Hewit, K., Sandilands, E., Martinez, R. S., James, D., Leung, H. Y., Bryant, D. M., ... & Markert, E. K. (2018). A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell death & disease, 9(11), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DLGAP5 Recombinant Antibody (EG968) (CAT#: V2LY-0425-LY466)

Related Products

Mouse Anti-DLGAP5 Recombinant Antibody (EG968) (CAT#: V2LY-0425-LY466)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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