Human DLGAP5 ELISA Kit (V2LY-0626-LY3335)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.31 ng/mL
Detection Range
0.5-300 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
95.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
DLG Associated Protein 5
Function
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Biological Process
Centrosome localization Source: GO_Central
Chromosome segregation Source: GO_Central
Kinetochore assembly Source: GO_Central
Mitotic chromosome movement towards spindle pole Source: UniProtKB
Mitotic spindle organization Source: GO_Central
Positive regulation of mitotic metaphase/anaphase transition Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Signaling Source: InterPro
Cellular Location
Spindle; Nucleus; Cytoplasm. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
PTM
Ubiquitinated, leading to its degradation.
Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.

Mamoor, S. (2021). Over-expression of DLG associated protein 5 in human endometrial cancer.

Branchi, V., García, S. A., Radhakrishnan, P., Győrffy, B., Hissa, B., Schneider, M., ... & Schölch, S. (2019). Prognostic value of DLGAP5 in colorectal cancer. International Journal of Colorectal Disease, 34(8), 1455-1465.

Hewit, K., Sandilands, E., Martinez, R. S., James, D., Leung, H. Y., Bryant, D. M., ... & Markert, E. K. (2018). A functional genomics screen reveals a strong synergistic effect between docetaxel and the mitotic gene DLGAP5 that is mediated by the androgen receptor. Cell death & disease, 9(11), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-DLGAP5 Recombinant Antibody (EG968) (CAT#: V2LY-0425-LY466)

Rabbit Anti-DLGAP5 Recombinant Antibody (EG968) (CAT#: CBMAB-EN1150-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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