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Mouse Anti-DLGAP5 Recombinant Antibody (EG968) (V2LY-0425-LY466)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
EG968
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 417-451 within an internal region of human HURP.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DLG Associated Protein 5
Entrez Gene ID
9787
UniProt ID
Q15398
Function
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Biological Process
Centrosome localization Source: GO_Central
Chromosome segregation Source: GO_Central
Kinetochore assembly Source: GO_Central
Mitotic chromosome movement towards spindle pole Source: UniProtKB
Mitotic spindle organization Source: GO_Central
Positive regulation of mitotic metaphase/anaphase transition Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Signaling Source: InterPro
Cellular Location
Spindle; Nucleus; Cytoplasm. Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
PTM
Ubiquitinated, leading to its degradation.
Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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