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Mouse Anti-DLK1 Recombinant Antibody (13B228) (CBMAB-D1059-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Delta Like Non-Canonical Notch Ligand 1 (DLK1). The antibody can be used for immunoassay techniques, such as ELISA, FC, WB.
See all DLK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13B228
Antibody Isotype
IgG1
Application
ELISA, FC, WB

Basic Information

Immunogen
Purified recombinant fragment of human DLK1 expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Delta Like Non-Canonical Notch Ligand 1
Introduction
DLK1 is a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.
Entrez Gene ID
8788
UniProt ID
P80370
Alternative Names
Delta Like Non-Canonical Notch Ligand 1; DLK-1; DLK; PG2; Delta-Like 1 Homolog (Drosophila); Delta-Like Homolog (Drosophila); Protein Delta Homolog 1; Preadipocyte Factor 1; Delta-Like 1 Homolog;
Function
May have a role in neuroendocrine differentiation.
Biological Process
Cell differentiation Source: Ensembl
Negative regulation of Notch signaling pathway Source: HGNC
Cellular Location
Cytoplasm; Membrane
Topology
Extracellular: 24-303
Helical: 304-327
Cytoplasmic: 328-383
PTM
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

Pittaway, J. F., Lipsos, C., Mariniello, K., & Guasti, L. (2021). The role of delta-like non-canonical Notch ligand 1 (DLK1) in cancer. Endocrine-related cancer, 28(12), R271-R287.

Mohammadabadi, M., Masoudzadeh, S. H., Khezri, A., Kalashnyk, O., Stavetska, R. V., Klopenko, N. I., ... & Tkachenko, S. V. (2021). Fennel (Foeniculum vulgare) seed powder increases Delta-Like Non-Canonical Notch Ligand 1 gene expression in testis, liver, and humeral muscle tissues of growing lambs. Heliyon, 7(12), e08542.

Pham, A., Sobrier, M. L., Giabicani, E., Le Jules Fernandes, M., Mitanchez, D., Brioude, F., & Netchine, I. (2021). Screening of patients born small for gestational age with the Silver-Russell syndrome phenotype for DLK1 variants. European Journal of Human Genetics, 29(12), 1756-1761.

Grassi, E. S., Pantazopoulou, V., & Pietras, A. (2020). Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma. Oncogene, 39(20), 4028-4044.

Traustadóttir, G. Á., Lagoni, L. V., Ankerstjerne, L. B. S., Bisgaard, H. C., Jensen, C. H., & Andersen, D. C. (2019). The imprinted gene Delta like non-canonical Notch ligand 1 (Dlk1) is conserved in mammals, and serves a growth modulatory role during tissue development and regeneration through Notch dependent and independent mechanisms. Cytokine & Growth Factor Reviews, 46, 17-27.

Jensen, C. H., Rydén, M., Baun, C., Hvidsten, S., Andersen, M. S., Christensen, L. L., ... & Andersen, D. C. (2019). The imprinted gene Delta like non-canonical notch ligand 1 (Dlk1) associates with obesity and triggers insulin resistance through inhibition of skeletal muscle glucose uptake. EBioMedicine, 46, 368-380.

Finn, J., Sottoriva, K., Pajcini, K. V., Kitajewski, J. K., Chen, C., Zhang, W., ... & Liu, Y. (2019). Dlk1-mediated temporal regulation of Notch signaling is required for differentiation of alveolar type II to type I cells during repair. Cell reports, 26(11), 2942-2954.

Huang, C. C., Kuo, H. M., Wu, P. C., Cheng, S. H., Chang, T. T., Chang, Y. C., ... & Tai, M. H. (2018). Soluble delta-like 1 homolog (DLK1) stimulates angiogenesis through Notch1/Akt/eNOS signaling in endothelial cells. Angiogenesis, 21(2), 299-312.

Traustadóttir, G. Á., Jensen, C. H., Ramirez, J. J. G., Beck, H. C., Sheikh, S. P., & Andersen, D. C. (2017). The non-canonical NOTCH1 ligand Delta-like 1 homolog (DLK1) self interacts in mammals. International journal of biological macromolecules, 97, 460-467.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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