DLK1

DLK1 is a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.
Full Name
Delta Like Non-Canonical Notch Ligand 1
Function
May have a role in neuroendocrine differentiation.
Biological Process
Cell differentiation Source: Ensembl
Negative regulation of Notch signaling pathway Source: HGNC
Cellular Location
Cytoplasm; Membrane
Topology
Extracellular: 24-303
Helical: 304-327
Cytoplasmic: 328-383
PTM
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
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Anti-DLK1 antibodies

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Rabbit Anti-DLK1 Recombinant Antibody (9D8) (CBMAB-D1061-YC)

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Target: DLK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 9D8
Application*: WB, IH, F
Datasheet SDS

Rat Anti-DLK1 Recombinant Antibody (D1063) (CBMAB-D1065-YC)

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Target: DLK1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: D1063
Application*: E, WB
Datasheet SDS

Mouse Anti-DLK1 Recombinant Antibody (D1062) (CBMAB-D1062-YC)

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Target: DLK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: D1062
Application*: WB, P, F, E
Datasheet SDS

Mouse Anti-DLK1 Recombinant Antibody (13B228) (CBMAB-D1059-YC)

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Target: DLK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13B228
Application*: E, F, WB, IF
Datasheet SDS

Mouse Anti-DLK1 Recombinant Antibody (CBT446) (V2LY-0625-LY3519)

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Target: DLK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT446
Application*: WB, IF, IC, F, E
Datasheet SDS

Mouse Anti-DLK1 Recombinant Antibody (CBT2035) (V2LY-0625-LY2649)

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Target: DLK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2035
Application*: IC, F
Datasheet SDS

Mouse Anti-DLK1 Recombinant Antibody (CBYC-P055) (V2LY-0425-LY472)

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Target: DLK1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-P055
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DLK1 Recombinant Antibody (D1060) (V2LY-0425-LY468)

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Target: DLK1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: D1060
Application*: WB, IH, IF, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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