DLK1

DLK1 is a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.

Delta Like Non-Canonical Notch Ligand 1

May have a role in neuroendocrine differentiation.

Cell differentiation Source: Ensembl
Negative regulation of Notch signaling pathway Source: HGNC

Cytoplasm; Membrane

Extracellular: 24-303
Helical: 304-327
Cytoplasmic: 328-383

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.