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Mouse Anti-DNAJC2 Recombinant Antibody (3F2) (CBMAB-D1312-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DnaJ Heat Shock Protein Family (Hsp40) Member C2 (DNAJC2). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DNAJC2 antibodies
Published Data
Fig. 1 Expression of ZRF1 in five GC cell lines and osteosarcoma cell lines, such as p53-null SaOS2 and p53 wild-type U2OS, compared with that in normal stomach and fibroblast cell line WI-38.
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Fig. 2 Specific immunostaining of ZRF1 in a representative primary tumor sample.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to a.a.408-509 from human ZRF1 (XP_168590) with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member C2
Introduction
DNAJC2 is a member of the M-phase phosphoprotein (MPP) family. DNAJC2 is a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors.
Entrez Gene ID
27000
UniProt ID
Q99543
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member C2; DnaJ (Hsp40) Homolog, Subfamily C, Member 2; M-Phase Phosphoprotein 11; Zuotin-Related Factor 1; MPHOSPH11; MPP11;
Function
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
Biological Process
de novo' cotranslational protein folding Source: UniProtKB
Chromatin organization Source: UniProtKB-KW
DNA replication Source: Ensembl
Negative regulation of DNA biosynthetic process Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of cellular response to heat Source: Reactome
Regulation of translational fidelity Source: InterPro
Cellular Location
Nucleus; Cytosol
PTM
Phosphorylated in M (mitotic) phase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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