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Rabbit Anti-DNAJC2 Recombinant Antibody (D1313) (V2LY-0425-LY651)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D1313
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding Pro540 of human DNAJC2/MPP11 protein.
Host Species
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:1,000
IP1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol & HEPES
Preservative
Sodium Azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member C2
Entrez Gene ID
Human27000
Mouse22791
Rat116456
Monkey695890
UniProt ID
HumanQ99543
MouseP54103
RatQ7TQ20
MonkeyQ4R8H2
Function
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
Biological Process
de novo' cotranslational protein folding Source: UniProtKB
Chromatin organization Source: UniProtKB-KW
DNA replication Source: Ensembl
Negative regulation of DNA biosynthetic process Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of cellular response to heat Source: Reactome
Regulation of translational fidelity Source: InterPro
Cellular Location
Nucleus; Cytosol
PTM
Phosphorylated in M (mitotic) phase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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