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Rabbit Anti-DNAJC2 Recombinant Antibody (D6B1E) (CBMAB-D1313-YC)

Provided herein is a Rabbit monoclonal antibody, which binds to DnaJ Heat Shock Protein Family (Hsp40) Member C2 (DNAJC2). The antibody can be used for immunoassay techniques, such as WB, IP.
See all DNAJC2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D6B1E
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member C2
Introduction
DNAJC2 is a member of the M-phase phosphoprotein (MPP) family. DNAJC2 is a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors.
Entrez Gene ID
Human27000
Mouse22791
Rat116456
Monkey695890
UniProt ID
HumanQ99543
MouseP54103
RatQ7TQ20
MonkeyQ4R8H2
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member C2; DnaJ (Hsp40) Homolog, Subfamily C, Member 2; M-Phase Phosphoprotein 11; Zuotin-Related Factor 1; MPHOSPH11; MPP11;
Function
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
Biological Process
de novo' cotranslational protein folding Source: UniProtKB
Chromatin organization Source: UniProtKB-KW
DNA replication Source: Ensembl
Negative regulation of DNA biosynthetic process Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Regulation of cellular response to heat Source: Reactome
Regulation of translational fidelity Source: InterPro
Cellular Location
Nucleus; Cytosol
PTM
Phosphorylated in M (mitotic) phase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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