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Mouse Anti-DND1 Recombinant Antibody (1F7) (CBMAB-D1346-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DND MicroRNA-Mediated Repression Inhibitor 1 (DND1). The antibody can be used for immunoassay techniques, such as ELISA, ICC, IF, WB.
See all DND1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F7
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
DND1 (NP_919225, 167 a.a. ~ 260 a.a) full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
dead end homolog 1 (zebrafish)
Introduction
DND1 is a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma.
Entrez Gene ID
373863
UniProt ID
Q8IYX4
Alternative Names
DND MicroRNA-Mediated Repression Inhibitor 1; RNA-Binding Motif, Single-Stranded-Interacting Protein 4; RBMS4; Dead End Homolog 1 (Zebrafish); Dead End Protein Homolog 1; Dead End Homolog 1;
Function
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity).

Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity).

However, does not seem to be essential for PGC migration (By similarity).
Biological Process
3'-UTR-mediated mRNA destabilization Source: CACAO
Germ cell development Source: Ensembl
mRNA stabilization Source: GO_Central
Negative regulation of gene silencing by miRNA Source: UniProtKB
Spermatogenesis Source: Ensembl
Cellular Location
Cytoplasm; Nucleus. Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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