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Mouse Anti-DND1 Recombinant Antibody (CBYCD-354) (V2LY-0425-LY676)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYCD-354
Antibody Isotype
IgG2a, κ
Application
WB, IP

Basic Information

Immunogen
Recombinant human DND1.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
dead end homolog 1 (zebrafish)
Entrez Gene ID
373863
UniProt ID
Q8IYX4
Function
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity).

Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity).

However, does not seem to be essential for PGC migration (By similarity).
Biological Process
3'-UTR-mediated mRNA destabilization Source: CACAO
Germ cell development Source: Ensembl
mRNA stabilization Source: GO_Central
Negative regulation of gene silencing by miRNA Source: UniProtKB
Spermatogenesis Source: Ensembl
Cellular Location
Cytoplasm; Nucleus. Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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