Mouse Anti-DND1 Recombinant Antibody (2G11) (V2LY-0425-LY675)

Name: Mouse Anti-DND1 Recombinant Antibody (2G11)
SKU: V2LY-0425-LY675
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2G11

Application

ELISA, WB

Immunogen

Full length recombinant DND1.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

dead end homolog 1 (zebrafish)

Entrez Gene ID

373863

UniProt ID

Q8IYX4

Function

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity).

Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity).

However, does not seem to be essential for PGC migration (By similarity).

Biological Process

3'-UTR-mediated mRNA destabilization Source: CACAO
Germ cell development Source: Ensembl
mRNA stabilization Source: GO_Central
Negative regulation of gene silencing by miRNA Source: UniProtKB
Spermatogenesis Source: Ensembl

Cellular Location

Cytoplasm; Nucleus. Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity).

Mall, E. M., Lecanda, A., Drexler, H. C., Raz, E., Schöler, H. R., & Schlatt, S. (2021). Heading towards a dead end: The role of DND1 in germ line differentiation of human iPSCs. PloS one, 16(10), e0258427.

Kumari, P., & Bhavesh, N. S. (2021). Human DND1‐RRM2 forms a non‐canonical domain swapped dimer. Protein Science, 30(6), 1184-1195.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DND1 Recombinant Antibody (2G11) (CAT#: CBMAB-D1347-YC)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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