DND1

DND1 is a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma.

dead end homolog 1 (zebrafish)

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity).

Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity).

However, does not seem to be essential for PGC migration (By similarity).

3'-UTR-mediated mRNA destabilization Source: CACAO
Germ cell development Source: Ensembl
mRNA stabilization Source: GO_Central
Negative regulation of gene silencing by miRNA Source: UniProtKB
Spermatogenesis Source: Ensembl

Cytoplasm; Nucleus. Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity).