DND1

DND1 is a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma.
Full Name
dead end homolog 1 (zebrafish)
Function
RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity).

Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs. Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs. Does not bind to miRNAs. May play a role during primordial germ cell (PGC) survival (By similarity).

However, does not seem to be essential for PGC migration (By similarity).
Biological Process
3'-UTR-mediated mRNA destabilization Source: CACAO
Germ cell development Source: Ensembl
mRNA stabilization Source: GO_Central
Negative regulation of gene silencing by miRNA Source: UniProtKB
Spermatogenesis Source: Ensembl
Cellular Location
Cytoplasm; Nucleus. Perinuclear germ granules, also called germ plasm or chromatoid body. Colocalizes in perinuclear sites with APOBEC3 (By similarity).
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Anti-DND1 antibodies

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Mouse Anti-DND1 Recombinant Antibody (2G9) (V2LY-0425-LY677)

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Target: DND1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 2G9
Application*: E
Datasheet SDS

Mouse Anti-DND1 Recombinant Antibody (CBYCD-354) (V2LY-0425-LY676)

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Target: DND1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYCD-354
Application*: WB, IP
Datasheet SDS

Mouse Anti-DND1 Recombinant Antibody (2G11) (V2LY-0425-LY675)

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Target: DND1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2G11
Application*: E, WB
Datasheet SDS

Mouse Anti-DND1 Recombinant Antibody (1F7) (V2LY-0425-LY674)

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Target: DND1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F7
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-DND1 Recombinant Antibody (2G9) (CBMAB-D1351-YC)

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Target: DND1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2G9
Application*: E
Datasheet SDS

Mouse Anti-DND1 Recombinant Antibody (CBYCD-354) (CBMAB-D1348-YC)

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Target: DND1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYCD-354
Application*: WB, F
Datasheet SDS

Mouse Anti-DND1 Recombinant Antibody (2G11) (CBMAB-D1347-YC)

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Target: DND1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2G11
Application*: WB
Datasheet SDS

Mouse Anti-DND1 Recombinant Antibody (1F7) (CBMAB-D1346-YC)

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Target: DND1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F7
Application*: E, IC, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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