Mouse Anti-DUSP22 Recombinant Antibody (3D3) (CBMAB-D1889-YC)

Name: Mouse Anti-DUSP22 Recombinant Antibody (3D3)
SKU: CBMAB-D1889-YC
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-DUSP22 Recombinant Antibody (3D3) (CBMAB-D1889-YC-1) in WB

H1299-JKAPTR cells and H1299-JKAP-CSTR cells were cultured with or without 2 μg/ml tetracycline (Tet) for 15 h. The protein levels and cell migration abilities were examined by Western blotting (left panel) or by Transwell assays (right panel), respectively. ...View More

Li, J. P., Fu, Y. N., Chen, Y. R., & Tan, T. H. (2010). JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. Journal of Biological Chemistry, 285(8), 5472-5478.

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3D3

Application

ELISA, WB

Immunogen

DUSP22 (aa112-184) partial recombinant protein.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 112-184

More Infomation

Target

Full Name

Dual Specificity Phosphatase 22

Introduction

DUSP22 (Dual Specificity Phosphatase 22) is a protein coding gene. Diseases associated with DUSP22 include Alk-Negative Anaplastic Large Cell Lymphoma and Lymphatic System Cancer. It has proved that the protein has phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. And a paralog is DUSP15.

Entrez Gene ID

56940

UniProt ID

Q9NRW4

Alternative Names

Dual Specificity Phosphatase 22; Low Molecular Weight Dual Specificity Phosphatase 2; Mitogen-Activated Protein Kinase Phosphatase X; JNK-Stimulatory Phosphatase-1; MAP Kinase Phosphatase X; LMW-DSP2; LMWDSP2; JSP-1; MKP-X; JSP1;

Research Area

Activates the Jnk signaling pathway.

Biological Process

Cellular response to epidermal growth factor stimulus Source: ARUK-UCL
Negative regulation of cell migration Source: ARUK-UCL
Negative regulation of focal adhesion assembly Source: ARUK-UCL
Negative regulation of non-membrane spanning protein tyrosine kinase activity Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: MGI
Peptidyl-tyrosine dephosphorylation Source: ARUK-UCL
Positive regulation of JNK cascade Source: GO_Central
Regulation of cell population proliferation Source: GO_Central
Transforming growth factor beta receptor signaling pathway Source: GO_Central

Cellular Location

Cytoplasm

PTM

Myristoylation regulates subcellular location, and is necessary for activation of JNK.

Qian, C., Chen, J., Xu, X., Liu, Q., Gu, M., Lu, S., ... & Xue, M. (2022). Measurement of synovium and serum dual specificity phosphatase 22 level: Their inter‐correlation and potency as biomarkers in rheumatoid arthritis. Journal of Clinical Laboratory Analysis, 36(1), e24111.

Cailing, E., Fang, Y., Wu, S., Meng, Z., Qin, G., & Yang, J. (2022). Dual specificity phosphatase 22 relates to skin lesion degree and biologics history, while its longitudinal elevation during treatment reflects better outcome in psoriasis patients. Journal of clinical laboratory analysis, 36(2).

Sasaki, Y., Fujimori, H., Hozumi, M., Onodera, T., Nozaki, T., Murakami, Y., ... & Masutani, M. (2019). Dysfunction of poly (ADP-ribose) glycohydrolase induces a synthetic lethal effect in dual specificity phosphatase 22-deficient lung cancer cells. Cancer Research, 79(15), 3851-3861.

Hamada, N., Mizuno, M., Tomita, H., Iwamoto, I., Hara, A., & Nagata, K. I. (2018). Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in mouse tissues. Medical Molecular Morphology, 51(2), 111-117.

Zhou, R., Chang, Y., Liu, J., Chen, M., Wang, H., Huang, M., ... & Zhao, Q. (2017). JNK pathway-associated phosphatase/DUSP22 suppresses CD4+ T-cell activation and Th1/Th17-cell differentiation and negatively correlates with clinical activity in inflammatory bowel disease. Frontiers in Immunology, 8, 781.

Pedersen, M. B., Hamilton-Dutoit, S. J., Bendix, K., Ketterling, R. P., Bedroske, P. P., Luoma, I. M., ... & Feldman, A. L. (2017). DUSP22 and TP63 rearrangements predict outcome of ALK-negative anaplastic large cell lymphoma: a Danish cohort study. Blood, The Journal of the American Society of Hematology, 130(4), 554-557.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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