Human Recombinant DUSP22, Active protein, GST Tag (V2LY-0526-LY3659)

Name: Human Recombinant DUSP22, Active protein, GST Tag
SKU: V2LY-0526-LY3659
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant DUSP22, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 43 kDa.

Molecule Mass

43 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Dual Specificity Phosphatase 22

Research Area

Activates the Jnk signaling pathway.

Biological Process

Cellular response to epidermal growth factor stimulus Source: ARUK-UCL
Negative regulation of cell migration Source: ARUK-UCL
Negative regulation of focal adhesion assembly Source: ARUK-UCL
Negative regulation of non-membrane spanning protein tyrosine kinase activity Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: MGI
Peptidyl-tyrosine dephosphorylation Source: ARUK-UCL
Positive regulation of JNK cascade Source: GO_Central
Regulation of cell population proliferation Source: GO_Central
Transforming growth factor beta receptor signaling pathway Source: GO_Central

Cellular Location

Cytoplasm

PTM

Myristoylation regulates subcellular location, and is necessary for activation of JNK.

Qian, C., Chen, J., Xu, X., Liu, Q., Gu, M., Lu, S., ... & Xue, M. (2022). Measurement of synovium and serum dual specificity phosphatase 22 level: Their inter‐correlation and potency as biomarkers in rheumatoid arthritis. Journal of Clinical Laboratory Analysis, 36(1), e24111.

Cailing, E., Fang, Y., Wu, S., Meng, Z., Qin, G., & Yang, J. (2022). Dual specificity phosphatase 22 relates to skin lesion degree and biologics history, while its longitudinal elevation during treatment reflects better outcome in psoriasis patients. Journal of clinical laboratory analysis, 36(2).

Sasaki, Y., Fujimori, H., Hozumi, M., Onodera, T., Nozaki, T., Murakami, Y., ... & Masutani, M. (2019). Dysfunction of poly (ADP-ribose) glycohydrolase induces a synthetic lethal effect in dual specificity phosphatase 22-deficient lung cancer cells. Cancer Research, 79(15), 3851-3861.

Hamada, N., Mizuno, M., Tomita, H., Iwamoto, I., Hara, A., & Nagata, K. I. (2018). Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in mouse tissues. Medical Molecular Morphology, 51(2), 111-117.

Zhou, R., Chang, Y., Liu, J., Chen, M., Wang, H., Huang, M., ... & Zhao, Q. (2017). JNK pathway-associated phosphatase/DUSP22 suppresses CD4+ T-cell activation and Th1/Th17-cell differentiation and negatively correlates with clinical activity in inflammatory bowel disease. Frontiers in Immunology, 8, 781.

Pedersen, M. B., Hamilton-Dutoit, S. J., Bendix, K., Ketterling, R. P., Bedroske, P. P., Luoma, I. M., ... & Feldman, A. L. (2017). DUSP22 and TP63 rearrangements predict outcome of ALK-negative anaplastic large cell lymphoma: a Danish cohort study. Blood, The Journal of the American Society of Hematology, 130(4), 554-557.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant DUSP22 protein, GST Tag (CAT#: V2LY-0526-LY3658)

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Human Recombinant DUSP22 protein, GST Tag (CAT#: V2LY-0526-LY3658)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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