DUSP22

DUSP22 (Dual Specificity Phosphatase 22) is a Protein Coding gene. Diseases associated with DUSP22 include Alk-Negative Anaplastic Large Cell Lymphoma and Lymphatic System Cancer. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP15.

Dual Specificity Phosphatase 22

Activates the Jnk signaling pathway.

Cellular response to epidermal growth factor stimulus Source: ARUK-UCL
Negative regulation of cell migration Source: ARUK-UCL
Negative regulation of focal adhesion assembly Source: ARUK-UCL
Negative regulation of non-membrane spanning protein tyrosine kinase activity Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: MGI
Peptidyl-tyrosine dephosphorylation Source: ARUK-UCL
Positive regulation of JNK cascade Source: GO_Central
Regulation of cell population proliferation Source: GO_Central
Transforming growth factor beta receptor signaling pathway Source: GO_Central

Cytoplasm

Myristoylation regulates subcellular location, and is necessary for activation of JNK.