DUSP22

DUSP22 (Dual Specificity Phosphatase 22) is a Protein Coding gene. Diseases associated with DUSP22 include Alk-Negative Anaplastic Large Cell Lymphoma and Lymphatic System Cancer. Gene Ontology (GO) annotations related to this gene include phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. An important paralog of this gene is DUSP15.

Full Name

Dual Specificity Phosphatase 22

Research Area

Activates the Jnk signaling pathway.

Biological Process

Cellular response to epidermal growth factor stimulus Source: ARUK-UCL
Negative regulation of cell migration Source: ARUK-UCL
Negative regulation of focal adhesion assembly Source: ARUK-UCL
Negative regulation of non-membrane spanning protein tyrosine kinase activity Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: MGI
Peptidyl-tyrosine dephosphorylation Source: ARUK-UCL
Positive regulation of JNK cascade Source: GO_Central
Regulation of cell population proliferation Source: GO_Central
Transforming growth factor beta receptor signaling pathway Source: GO_Central

Cellular Location

Cytoplasm

PTM

Myristoylation regulates subcellular location, and is necessary for activation of JNK.