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Mouse Anti-DUSP22 Recombinant Antibody (CBYCD-445) (V2LY-0425-LY1063)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-445
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IP

Basic Information

Immunogen
Recombinant human DUSP22 protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dual Specificity Phosphatase 22
Entrez Gene ID
56940
UniProt ID
Q9NRW4
Research Area
Activates the Jnk signaling pathway.
Biological Process
Cellular response to epidermal growth factor stimulus Source: ARUK-UCL
Negative regulation of cell migration Source: ARUK-UCL
Negative regulation of focal adhesion assembly Source: ARUK-UCL
Negative regulation of non-membrane spanning protein tyrosine kinase activity Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: MGI
Peptidyl-tyrosine dephosphorylation Source: ARUK-UCL
Positive regulation of JNK cascade Source: GO_Central
Regulation of cell population proliferation Source: GO_Central
Transforming growth factor beta receptor signaling pathway Source: GO_Central
Cellular Location
Cytoplasm
PTM
Myristoylation regulates subcellular location, and is necessary for activation of JNK.
More Infomation

Qian, C., Chen, J., Xu, X., Liu, Q., Gu, M., Lu, S., ... & Xue, M. (2022). Measurement of synovium and serum dual specificity phosphatase 22 level: Their inter‐correlation and potency as biomarkers in rheumatoid arthritis. Journal of Clinical Laboratory Analysis, 36(1), e24111.

Cailing, E., Fang, Y., Wu, S., Meng, Z., Qin, G., & Yang, J. (2022). Dual specificity phosphatase 22 relates to skin lesion degree and biologics history, while its longitudinal elevation during treatment reflects better outcome in psoriasis patients. Journal of clinical laboratory analysis, 36(2).

Sasaki, Y., Fujimori, H., Hozumi, M., Onodera, T., Nozaki, T., Murakami, Y., ... & Masutani, M. (2019). Dysfunction of poly (ADP-ribose) glycohydrolase induces a synthetic lethal effect in dual specificity phosphatase 22-deficient lung cancer cells. Cancer Research, 79(15), 3851-3861.

Hamada, N., Mizuno, M., Tomita, H., Iwamoto, I., Hara, A., & Nagata, K. I. (2018). Expression analyses of Dusp22 (Dual-specificity phosphatase 22) in mouse tissues. Medical Molecular Morphology, 51(2), 111-117.

Zhou, R., Chang, Y., Liu, J., Chen, M., Wang, H., Huang, M., ... & Zhao, Q. (2017). JNK pathway-associated phosphatase/DUSP22 suppresses CD4+ T-cell activation and Th1/Th17-cell differentiation and negatively correlates with clinical activity in inflammatory bowel disease. Frontiers in Immunology, 8, 781.

Pedersen, M. B., Hamilton-Dutoit, S. J., Bendix, K., Ketterling, R. P., Bedroske, P. P., Luoma, I. M., ... & Feldman, A. L. (2017). DUSP22 and TP63 rearrangements predict outcome of ALK-negative anaplastic large cell lymphoma: a Danish cohort study. Blood, The Journal of the American Society of Hematology, 130(4), 554-557.

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For research use only. Not intended for any clinical use.

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