Mouse Anti-GDI1 Recombinant Antibody (4E1G1) (CBMAB-AP2487LY)

Name: Mouse Anti-GDI1 Recombinant Antibody (4E1G1)
SKU: CBMAB-AP2487LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4E1G1

Application

ELISA, WB

Immunogen

Fusion Protein of GDI1

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

GDP Dissociation Inhibitor 1

Introduction

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	2664
Mouse	14567
Rat	25183

UniProt ID

Human	P31150
Mouse	P50396
Rat	P50398

Alternative Names

GDP Dissociation Inhibitor 1; Guanosine Diphosphate Dissociation Inhibitor 1; Rab GDP-Dissociation Inhibitor, Alpha; Mental Retardation, X-Linked 48; Oligophrenin-2; Protein XAP-4; Rab GDI Alpha; RABGDIA; GDI-1; OPHN2; GDIL;

Function

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.

Biological Process

Negative regulation of axonogenesis Source: UniProtKB
Negative regulation of protein targeting to membrane Source: UniProtKB
Positive regulation of axon extension Source: Ensembl
Protein transport Source: InterPro
Rab protein signal transduction Source: UniProtKB
Response to calcium ion Source: Ensembl
Signal transduction Source: ProtInc
Vesicle-mediated transport Source: GO_Central

Cellular Location

Cytoplasm; Trans-Golgi network

Involvement in disease

Mental retardation, X-linked 41 (MRX41):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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