GDI1

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008]

GDP Dissociation Inhibitor 1

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.

Negative regulation of axonogenesis Source: UniProtKB
Negative regulation of protein targeting to membrane Source: UniProtKB
Positive regulation of axon extension Source: Ensembl
Protein transport Source: InterPro
Rab protein signal transduction Source: UniProtKB
Response to calcium ion Source: Ensembl
Signal transduction Source: ProtInc
Vesicle-mediated transport Source: GO_Central

Cytoplasm; Trans-Golgi network

Mental retardation, X-linked 41 (MRX41):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.