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GDI1

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008]
Full Name
GDP Dissociation Inhibitor 1
Function
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
Biological Process
Negative regulation of axonogenesis Source: UniProtKB
Negative regulation of protein targeting to membrane Source: UniProtKB
Positive regulation of axon extension Source: Ensembl
Protein transport Source: InterPro
Rab protein signal transduction Source: UniProtKB
Response to calcium ion Source: Ensembl
Signal transduction Source: ProtInc
Vesicle-mediated transport Source: GO_Central
Cellular Location
Cytoplasm; Trans-Golgi network
Involvement in disease
Mental retardation, X-linked 41 (MRX41):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
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Anti-GDI1 antibodies

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Mouse Anti-GDI1 Recombinant Antibody (4E1G1) (CBMAB-AP2487LY)

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Target: GDI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 4E1G1
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-GDI1 Recombinant Antibody (CBLG1-846) (CBMAB-G2782-LY)

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Target: GDI1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-846
Application*: WB
Datasheet SDS

Mouse Anti-GDI1 Recombinant Antibody (1H3) (CBMAB-G2777-LY)

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Target: GDI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H3
Application*: WB
Datasheet SDS

Mouse Anti-GDI1 Recombinant Antibody (D-2) (CBMAB-R0535-CN)

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Target: GDI1
Host: Mouse
Specificity: Human
Clone: D-2
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-GDI1 Recombinant Antibody (CBCNR-084) (CBMAB-R0534-CN)

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Target: GDI1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse, Hamster, Cattle
Clone: CBCNR-084
Application*: ICC, IP, WB
Datasheet SDS

Mouse Anti-GDI1 ( AA 1-447) Recombinant Antibody (CBFYH-0314) (CBMAB-H1185-FY)

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Target: GDI1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0314
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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