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Mouse Anti-GDI1 Recombinant Antibody (CBCNR-084) (CBMAB-R0534-CN)

This product is a Mouse antibody that recognizes GDI1. The antibody CBCNR-084 can be used for immunoassay techniques such as: ICC, IP, WB.
See all GDI1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse, Hamster, Cattle
Clone
CBCNR-084
Antibody Isotype
IgG1
Application
ICC, IP, WB

Basic Information

Specificity
Human, Rat, Mouse, Hamster, Cattle
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
GDP Dissociation Inhibitor 1
Introduction
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human2664
Mouse14567
Rat25183
Hamster101826762
Cattle281188
UniProt ID
HumanP31150
MouseP50396
RatP50398
HamsterA0A1U7R6A7
CattleP21856
Alternative Names
GDP Dissociation Inhibitor 1; Guanosine Diphosphate Dissociation Inhibitor 1; Rab GDP-Dissociation Inhibitor, Alpha; Mental Retardation, X-Linked 48; Oligophrenin-2; Protein XAP-4; Rab GDI Alpha; RABGDIA; GDI-1; OPHN2; GDIL;
Function
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
Biological Process
Negative regulation of axonogenesis Source: UniProtKB
Negative regulation of protein targeting to membrane Source: UniProtKB
Positive regulation of axon extension Source: Ensembl
Protein transport Source: InterPro
Rab protein signal transduction Source: UniProtKB
Response to calcium ion Source: Ensembl
Signal transduction Source: ProtInc
Vesicle-mediated transport Source: GO_Central
Cellular Location
Cytoplasm; Trans-Golgi network
Involvement in disease
Mental retardation, X-linked 41 (MRX41):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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