Mouse Anti-GIPR Recombinant Antibody (591815) (CBMAB-G0477-LY)

Name: Mouse Anti-GIPR Recombinant Antibody (591815)
SKU: CBMAB-G0477-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

591815

Application

Immunogen

NS0 mouse myeloma cell line transfected with human GIPR (amino acids 1-466)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Gastric Inhibitory Polypeptide Receptor

Introduction

This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]

Entrez Gene ID

2696

UniProt ID

P48546

Alternative Names

Gastric Inhibitory Polypeptide Receptor; Glucose-Dependent Insulinotropic Polypeptide Receptor; GIP-R; PGQTL2;

Function

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Biological Process

Activation of adenylate cyclase activity Source: ProtInc
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Desensitization of G protein-coupled receptor signaling pathway Source: Ensembl
Endocrine pancreas development Source: Ensembl
Gastric inhibitory peptide signaling pathway Source: BHF-UCL
Generation of precursor metabolites and energy Source: ProtInc
Positive regulation of cAMP-mediated signaling Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Positive regulation of insulin secretion Source: Ensembl
Regulation of insulin secretion Source: ParkinsonsUK-UCL
Response to axon injury Source: Ensembl
Response to calcium ion Source: Ensembl
Response to fatty acid Source: Ensembl
Response to glucose Source: Ensembl
Response to nutrient Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 22-138
Helical: 139-161
Cytoplasmic: 162-169
Helical: 170-189
Extracellular: 190-217
Helical: 218-242
Cytoplasmic: 243-254
Helical: 255-278
Extracellular: 279-293
Helical: 294-319
Cytoplasmic: 320-341
Helical: 342-362
Extracellular: 363-377
Helical: 378-398
Cytoplasmic: 399-466

PTM

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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