Mouse Anti-GMEB1 Antibody (1C1) (CBMAB-0413-YC)

Name: Mouse Anti-GMEB1 Antibody (1C1)
SKU: CBMAB-0413-YC
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1C1

Antibody Isotype

IgG2b

Application

IP, WB, MA

Basic Information

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

GMEB1

Introduction

The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. GMEB1 (glucocorticoid modulatory element binding protein 1) is a member of KDWK gene family which associates with GMEB2 protein. GMEB1's role may be to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist.

Entrez Gene ID

10691

UniProt ID

Q9Y692

Alternative Names

P96PIF; PIF96

Function

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Biological Process

Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Cytoplasm; Nucleus. May be also cytoplasmic.

More Infomation

References

Cui, Z., Sun, Q., Yan, W., Han, Q., Wang, G., & Hu, Y. (2021). The role of miR‐320a and its target gene GMEB1 in epithelial‐mesenchymal transition and invasion of colorectal cancer. The Journal of Gene Medicine, e3327.

Kotsaris, G., Kerselidou, D., Koutsoubaris, D., Constantinou, E., Malamas, G., Garyfallos, D. A., & Ηatzivassiliou, E. G. (2020). TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function. Journal of Biological Research-Thessaloniki, 27, 1-7.

An, W., Yao, S., Sun, X., Hou, Z., Lin, Y., Su, L., & Liu, X. (2019). Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR L and inhibit apoptosis in human non-small cell lung cancer cells. Journal of Experimental & Clinical Cancer Research, 38, 1-13.

Tuesta, L. M., Djekidel, M. N., Chen, R., Lu, F., Wang, W., Sabatini, B. L., & Zhang, Y. (2019). In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function. Nature communications, 10(1), 2508.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

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Mouse Anti-GMEB1 Recombinant Antibody (CBLG1-1357)

Mouse Anti-GMEB1 Recombinant Antibody (CBLG1-1359)

Mouse Anti-GMEB1 (AA 467-564) Recombinant Antibody (CBFYH-0399)

Mouse Anti-GMEB1 Recombinant Antibody (2A8)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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