Mouse Anti-GMEB1 Recombinant Antibody (CBFYH-0399) (CBMAB-H1270-FY)

Name: Mouse Anti-GMEB1 Recombinant Antibody (CBFYH-0399)
SKU: CBMAB-H1270-FY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-GMEB1 Recombinant Antibody (CBFYH-0399) (CBMAB-H1270-FY) in IF

Calu-1 cells were fixed and subjected to indirect immunofluorescence staining with anti-FLIPL and GMEB1. The red signal (CFLARL) was obtained with anti-rabbit IgG Alexa 568-conjugated secondary Ab, and the green signals (GMEB1) were obtained with anti-mouse IgG Alexa 488-conjugated secondary Ab. ...View More

An, W., Yao, S., Sun, X., Hou, Z., Lin, Y., Su, L., & Liu, X. (2019). Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells. Journal of experimental & clinical cancer research : CR, 38(1), 181. https://doi.org/10.1186/s13046-019-1182-3

Datasheet

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-0399

Application

WB, ELISA, IF, IP, IHC-P

Immunogen

Amino acids 225-319 mapping within an internal region of mouse GMEB-1.

Specificity

Human, Mouse, Rat, Horse, Dog, Cattle

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 467-564

More Infomation

Target

Full Name

GMEB1

Introduction

This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist.

Entrez Gene ID

10691

UniProt ID

Q9Y692

Alternative Names

Glucocorticoid Modulatory Element Binding Protein 1; Parvovirus Initiation Factor P96; DNA-Binding Protein P96PIF; PIF P96; Glucocorticoid Modulatory Element-Binding Protein 1; P96PIF; GMEB-1; PIF96

Function

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Biological Process

Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Cytoplasm; Nucleus. May be also cytoplasmic.

Cui, Z., Sun, Q., Yan, W., Han, Q., Wang, G., & Hu, Y. (2021). The role of miR‐320a and its target gene GMEB1 in epithelial‐mesenchymal transition and invasion of colorectal cancer. The Journal of Gene Medicine, e3327.

Kotsaris, G., Kerselidou, D., Koutsoubaris, D., Constantinou, E., Malamas, G., Garyfallos, D. A., & Ηatzivassiliou, E. G. (2020). TRAF3 can interact with GMEB1 and modulate its anti-apoptotic function. Journal of Biological Research-Thessaloniki, 27, 1-7.

An, W., Yao, S., Sun, X., Hou, Z., Lin, Y., Su, L., & Liu, X. (2019). Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLAR L and inhibit apoptosis in human non-small cell lung cancer cells. Journal of Experimental & Clinical Cancer Research, 38, 1-13.

Tuesta, L. M., Djekidel, M. N., Chen, R., Lu, F., Wang, W., Sabatini, B. L., & Zhang, Y. (2019). In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function. Nature communications, 10(1), 2508.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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