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Mouse Anti-GRM8 Recombinant Antibody (220310) (CBMAB-G5051-LY)

This product is antibody recognizes GRM8. The antibody 220310 immunoassay techniques such as: IHC-P, WB.
See all GRM8 antibodies
Published Data
Fig.1 Confocal immunofluorescent staining images of MCA showing the presence of NGAL protein.
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Fig.2 Immunoblotting detected lcn2 in the culture medium.
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Fig.3 Western blot of NGAL in conditioned media with Coomassie brilliant blue-stained media (CBB) as a loading control.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
220310
Antibody Isotype
IgG2b
Application
IHC-P, WB

Basic Information

Immunogen
CHO-derived rhmGluR8
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutamate metabotropic receptor 8
Introduction
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2918
UniProt ID
O00222
Alternative Names
Glutamate Metabotropic Receptor 8; Glutamate Receptor; Metabotropic 8; GPRC1H; MGLUR8; Metabotropic Glutamate Receptor 8; GLUR8; MGlu8;
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Visual perception Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 34-583
Helical: 584-608
Cytoplasmic: 609-620
Helical: 621-641
Extracellular: 642-647
Helical: 648-668
Cytoplasmic: 669-695
Helical: 696-716
Extracellular: 717-746
Helical: 747-768
Cytoplasmic: 769-781
Helical: 782-803
Extracellular: 804-818
Helical: 819-843
Cytoplasmic: 844-908
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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