Mouse Anti-GRM8 Recombinant Antibody (CBLG1-1805) (CBMAB-G5055-LY)

Name: Mouse Anti-GRM8 Recombinant Antibody (CBLG1-1805)
SKU: CBMAB-G5055-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-1805

Application

ELISA, ELISA (Cap), WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

glutamate metabotropic receptor 8

Introduction

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

2918

UniProt ID

O00222

Alternative Names

Glutamate Metabotropic Receptor 8; Glutamate Receptor; Metabotropic 8; GPRC1H; MGLUR8; Metabotropic Glutamate Receptor 8; GLUR8; MGlu8;

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Visual perception Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 34-583
Helical: 584-608
Cytoplasmic: 609-620
Helical: 621-641
Extracellular: 642-647
Helical: 648-668
Cytoplasmic: 669-695
Helical: 696-716
Extracellular: 717-746
Helical: 747-768
Cytoplasmic: 769-781
Helical: 782-803
Extracellular: 804-818
Helical: 819-843
Cytoplasmic: 844-908

Poltavskaya, E. G., Tiguntsev, V. V., Boiko, A. S., Kornetova, E. G., Ivanova, S. A., & Fedorenko, O. Y. (2023). Study of Associations of the GRM8 Gene with Antipsychoticinduced Hyperprolactinemia. Personalized Psychiatry and Neurology, 3(1), 42-47.

Zhang, C., Xie, S., Yuan, S., Zhang, Y., Bai, Y., Chu, L., ... & Zhang, J. (2021). Metabotropic Glutamate Receptor 8 Is Regulated by miR-33a-5p and Functions as an Oncogene in Breast Cancer. Journal of Oncology, 2021.

Woo, M. S., Ufer, F., Rothammer, N., Di Liberto, G., Binkle, L., Haferkamp, U., ... & Friese, M. A. (2021). Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation. Journal of Experimental Medicine, 218(5).

Zhang, P., Kang, B., Xie, G., Li, S., Gu, Y., Shen, Y., ... & Yang, Y. (2019). Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. Cancer letters, 442, 53-67.

Jantas, D., Grygier, B., Gołda, S., Chwastek, J., Zatorska, J., & Tertil, M. (2018). An endogenous and ectopic expression of metabotropic glutamate receptor 8 (mGluR8) inhibits proliferation and increases chemosensitivity of human neuroblastoma and glioma cells. Cancer Letters, 432, 1-16.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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