Mouse Anti-GRM8 Recombinant Antibody (CBT2200) (V2LY-0625-LY888)

Name: Mouse Anti-GRM8 Recombinant Antibody (CBT2200)
SKU: V2LY-0625-LY888
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBT2200

Antibody Isotype

IgG1

Application

WB, FC

Basic Information

Immunogen

Purified recombinant fragment of human GRM8 (AA: extra 440-583) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

glutamate metabotropic receptor 8

Entrez Gene ID

2918

UniProt ID

O00222

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Visual perception Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 34-583
Helical: 584-608
Cytoplasmic: 609-620
Helical: 621-641
Extracellular: 642-647
Helical: 648-668
Cytoplasmic: 669-695
Helical: 696-716
Extracellular: 717-746
Helical: 747-768
Cytoplasmic: 769-781
Helical: 782-803
Extracellular: 804-818
Helical: 819-843
Cytoplasmic: 844-908

More Infomation

References

Poltavskaya, E. G., Tiguntsev, V. V., Boiko, A. S., Kornetova, E. G., Ivanova, S. A., & Fedorenko, O. Y. (2023). Study of Associations of the GRM8 Gene with Antipsychoticinduced Hyperprolactinemia. Personalized Psychiatry and Neurology, 3(1), 42-47.

Zhang, C., Xie, S., Yuan, S., Zhang, Y., Bai, Y., Chu, L., ... & Zhang, J. (2021). Metabotropic Glutamate Receptor 8 Is Regulated by miR-33a-5p and Functions as an Oncogene in Breast Cancer. Journal of Oncology, 2021.

Woo, M. S., Ufer, F., Rothammer, N., Di Liberto, G., Binkle, L., Haferkamp, U., ... & Friese, M. A. (2021). Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation. Journal of Experimental Medicine, 218(5).

Zhang, P., Kang, B., Xie, G., Li, S., Gu, Y., Shen, Y., ... & Yang, Y. (2019). Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. Cancer letters, 442, 53-67.

Jantas, D., Grygier, B., Gołda, S., Chwastek, J., Zatorska, J., & Tertil, M. (2018). An endogenous and ectopic expression of metabotropic glutamate receptor 8 (mGluR8) inhibits proliferation and increases chemosensitivity of human neuroblastoma and glioma cells. Cancer Letters, 432, 1-16.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Mouse Anti-GRM8 Recombinant Antibody (CBLG1-1805)

Mouse Anti-GRM8 (AA 34-514 ) Recombinant Antibody (CBFYM-1116)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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