Sign in or Register   Sign in or Register
  |  

Mouse Anti-HAS3 Recombinant Antibody (CBFYH-0713) (CBMAB-H1602-FY)

This product is mouse antibody that recognizes HAS3. The antibody CBFYH-0713 can be used for immunoassay techniques such as: ELISA, FC, IHC, WB.
See all HAS3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0713
Antibody Isotype
IgG1
Application
ELISA, FC, IHC, WB

Basic Information

Immunogen
Purified recombinant fragment of human HAS3 expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Hyaluronan Synthase 3
Introduction
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
3038
UniProt ID
O00219
Alternative Names
Hyaluronan Synthase 3; Hyaluronic Acid Synthase 3; Hyaluronate Synthase 3; HA Synthase 3; EC 2.4.1.212
Function
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).
Biological Process
Carbohydrate metabolic process Source: ProtInc
Extracellular matrix assembly Source: UniProtKB
Extracellular polysaccharide biosynthetic process Source: UniProtKB
Hyaluronan biosynthetic process Source: UniProtKB
Positive regulation of hyaluranon cable assembly Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Membrane
Topology
Cytoplasmic: 1-15
Helical: 16-36
Extracellular: 37-44
Helical: 45-65
Cytoplasmic: 66-377
Helical: 378-398
Extracellular: 399-408
Helical: 409-429
Cytoplasmic: 430-440
Helical: 441-461
Extracellular: 462-473
Helical: 474-494
Cytoplasmic: 495-515
Helical: 516-536
Extracellular: 537-553

Chen, Q., Peng, Q., Cai, J., Liu, Y., Lu, X., Xiong, W., ... & Chen, P. (2023). Super Enhancer Driven Hyaluronan Synthase 3 Promotes Malignant Progression of Nasopharyngeal Carcinoma. Journal of Cancer, 14(10), 1751-1762.

Piroth, M., Gorski, D. J., Hundhausen, C., Petz, A., Gorressen, S., Semmler, D., ... & Fischer, J. W. (2022). Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response. Matrix Biology, 112, 116-131.

Mayer, C. A., Ganguly, A., Mayer, A., Pabelick, C. M., Prakash, Y. S., Hascall, V. C., ... & MacFarlane, P. M. (2022). CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3. Pediatric research, 92(3), 685-693.

Ota, Y., Yoshida, H., Endo, Y., Sayo, T., & Takahashi, Y. (2022). A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. International Journal of Molecular Sciences, 23(5), 2424.

Schneckmann, R., Suvorava, T., Hundhausen, C., Schuler, D., Lorenz, C., Freudenberger, T., ... & Grandoch, M. (2021). Endothelial hyaluronan synthase 3 augments postischemic arteriogenesis through CD44/eNOS signaling. Arteriosclerosis, thrombosis, and vascular biology, 41(10), 2551-2562.

Hundhausen, C., Schneckmann, R., Ostendorf, Y., Rimpler, J., von Glinski, A., Kohlmorgen, C., ... & Grandoch, M. (2021). Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease. Matrix Biology, 102, 20-36.

Lee, W. J., Chen, L. C., Lin, J. H., Cheng, T. C., Kuo, C. C., Wu, C. H., ... & Ho, Y. S. (2019). Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy. Cancer Medicine, 8(10), 4821-4835.

Homann, S., Grandoch, M., Kiene, L. S., Podsvyadek, Y., Feldmann, K., Rabausch, B., ... & Fischer, J. W. (2018). Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression. Matrix Biology, 66, 67-80.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-HAS3 Recombinant Antibody (CBFYH-0713)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare