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HAS3

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants.

Full Name

Hyaluronan Synthase 3

Function

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).

Biological Process

Carbohydrate metabolic process Source: ProtInc
Extracellular matrix assembly Source: UniProtKB
Extracellular polysaccharide biosynthetic process Source: UniProtKB
Hyaluronan biosynthetic process Source: UniProtKB
Positive regulation of hyaluranon cable assembly Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Membrane

Topology

Cytoplasmic: 1-15
Helical: 16-36
Extracellular: 37-44
Helical: 45-65
Cytoplasmic: 66-377
Helical: 378-398
Extracellular: 399-408
Helical: 409-429
Cytoplasmic: 430-440
Helical: 441-461
Extracellular: 462-473
Helical: 474-494
Cytoplasmic: 495-515
Helical: 516-536
Extracellular: 537-553

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Anti-HAS3 antibodies

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Human HAS3 ELISA Kit (V2LY-0626-LY3657)

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Target: HAS3

Sensitivity: 0.0099 ng/mL

Detection Range: 0.02-6 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Mouse Has3 ELISA Kit (V2LY-0626-LY1492)

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Target: Has3

Sensitivity: 0.0093 ng/mL

Detection Range: 0.02-3.8 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Mouse

Assay Type: Sandwich

Reactivity: Mouse

Mouse Anti-HAS3 Recombinant Antibody (CBT2969) (V2LY-0625-LY2771)

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Target: HAS3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT2969

Application*: IH, F

Mouse Anti-HAS3 Recombinant Antibody (CBFYH-0714) (CBMAB-H1603-FY)

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Target: HAS3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0714

Application*: WB, P, F

Mouse Anti-HAS3 Recombinant Antibody (CBFYH-0713) (CBMAB-H1602-FY)

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Target: HAS3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0713

Application*: E, F, IH, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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