HAS3

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants.

Full Name

Hyaluronan Synthase 3

Function

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).

Biological Process

Carbohydrate metabolic process Source: ProtInc
Extracellular matrix assembly Source: UniProtKB
Extracellular polysaccharide biosynthetic process Source: UniProtKB
Hyaluronan biosynthetic process Source: UniProtKB
Positive regulation of hyaluranon cable assembly Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Membrane

Topology

Cytoplasmic: 1-15
Helical: 16-36
Extracellular: 37-44
Helical: 45-65
Cytoplasmic: 66-377
Helical: 378-398
Extracellular: 399-408
Helical: 409-429
Cytoplasmic: 430-440
Helical: 441-461
Extracellular: 462-473
Helical: 474-494
Cytoplasmic: 495-515
Helical: 516-536
Extracellular: 537-553