Mouse Anti-HAS3 Recombinant Antibody (CBT2969) (V2LY-0625-LY2771)

Name: Mouse Anti-HAS3 Recombinant Antibody (CBT2969)
SKU: V2LY-0625-LY2771
Rating: 5 (1 reviews)

See all HAS3 antibodies

Compare Online Inquiry

Tested Data

Mouse Anti-HAS3 Recombinant Antibody (CBT2969) (V2LY-0625-LY2771) in WB

Mouse Anti-HAS3 Recombinant Antibody (CBT2969) (V2LY-0625-LY2771) in IHC

Mouse Anti-HAS3 Recombinant Antibody (CBT2969) (V2LY-0625-LY2771) in FC

Mouse Anti-HAS3 Recombinant Antibody (CBT2969) (V2LY-0625-LY2771) in ELISA

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2969

Application

IHC, FC

Immunogen

Purified recombinant fragment of human HAS3 expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Hyaluronan Synthase 3

Entrez Gene ID

3038

UniProt ID

O00219

Function

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).

Biological Process

Carbohydrate metabolic process Source: ProtInc
Extracellular matrix assembly Source: UniProtKB
Extracellular polysaccharide biosynthetic process Source: UniProtKB
Hyaluronan biosynthetic process Source: UniProtKB
Positive regulation of hyaluranon cable assembly Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Membrane

Topology

Cytoplasmic: 1-15
Helical: 16-36
Extracellular: 37-44
Helical: 45-65
Cytoplasmic: 66-377
Helical: 378-398
Extracellular: 399-408
Helical: 409-429
Cytoplasmic: 430-440
Helical: 441-461
Extracellular: 462-473
Helical: 474-494
Cytoplasmic: 495-515
Helical: 516-536
Extracellular: 537-553

Chen, Q., Peng, Q., Cai, J., Liu, Y., Lu, X., Xiong, W., ... & Chen, P. (2023). Super Enhancer Driven Hyaluronan Synthase 3 Promotes Malignant Progression of Nasopharyngeal Carcinoma. Journal of Cancer, 14(10), 1751-1762.

Piroth, M., Gorski, D. J., Hundhausen, C., Petz, A., Gorressen, S., Semmler, D., ... & Fischer, J. W. (2022). Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response. Matrix Biology, 112, 116-131.

Mayer, C. A., Ganguly, A., Mayer, A., Pabelick, C. M., Prakash, Y. S., Hascall, V. C., ... & MacFarlane, P. M. (2022). CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3. Pediatric research, 92(3), 685-693.

Ota, Y., Yoshida, H., Endo, Y., Sayo, T., & Takahashi, Y. (2022). A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. International Journal of Molecular Sciences, 23(5), 2424.

Schneckmann, R., Suvorava, T., Hundhausen, C., Schuler, D., Lorenz, C., Freudenberger, T., ... & Grandoch, M. (2021). Endothelial hyaluronan synthase 3 augments postischemic arteriogenesis through CD44/eNOS signaling. Arteriosclerosis, thrombosis, and vascular biology, 41(10), 2551-2562.

Hundhausen, C., Schneckmann, R., Ostendorf, Y., Rimpler, J., von Glinski, A., Kohlmorgen, C., ... & Grandoch, M. (2021). Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease. Matrix Biology, 102, 20-36.

Lee, W. J., Chen, L. C., Lin, J. H., Cheng, T. C., Kuo, C. C., Wu, C. H., ... & Ho, Y. S. (2019). Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy. Cancer Medicine, 8(10), 4821-4835.

Homann, S., Grandoch, M., Kiene, L. S., Podsvyadek, Y., Feldmann, K., Rabausch, B., ... & Fischer, J. W. (2018). Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression. Matrix Biology, 66, 67-80.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-HAS3 Recombinant Antibody (CBT2969)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-HAS3 Recombinant Antibody (CBFYH-0713) (CAT#: CBMAB-H1602-FY)

Mouse Anti-HAS3 Recombinant Antibody (CBFYH-0714) (CAT#: CBMAB-H1603-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry