Human HAS3 ELISA Kit (V2LY-0626-LY3657)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0099 ng/mL
Detection Range
0.02-6 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
63.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Hyaluronan Synthase 3
Function
Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).
Biological Process
Carbohydrate metabolic process Source: ProtInc
Extracellular matrix assembly Source: UniProtKB
Extracellular polysaccharide biosynthetic process Source: UniProtKB
Hyaluronan biosynthetic process Source: UniProtKB
Positive regulation of hyaluranon cable assembly Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Membrane
Topology
Cytoplasmic: 1-15
Helical: 16-36
Extracellular: 37-44
Helical: 45-65
Cytoplasmic: 66-377
Helical: 378-398
Extracellular: 399-408
Helical: 409-429
Cytoplasmic: 430-440
Helical: 441-461
Extracellular: 462-473
Helical: 474-494
Cytoplasmic: 495-515
Helical: 516-536
Extracellular: 537-553

Chen, Q., Peng, Q., Cai, J., Liu, Y., Lu, X., Xiong, W., ... & Chen, P. (2023). Super Enhancer Driven Hyaluronan Synthase 3 Promotes Malignant Progression of Nasopharyngeal Carcinoma. Journal of Cancer, 14(10), 1751-1762.

Piroth, M., Gorski, D. J., Hundhausen, C., Petz, A., Gorressen, S., Semmler, D., ... & Fischer, J. W. (2022). Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response. Matrix Biology, 112, 116-131.

Mayer, C. A., Ganguly, A., Mayer, A., Pabelick, C. M., Prakash, Y. S., Hascall, V. C., ... & MacFarlane, P. M. (2022). CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3. Pediatric research, 92(3), 685-693.

Ota, Y., Yoshida, H., Endo, Y., Sayo, T., & Takahashi, Y. (2022). A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. International Journal of Molecular Sciences, 23(5), 2424.

Schneckmann, R., Suvorava, T., Hundhausen, C., Schuler, D., Lorenz, C., Freudenberger, T., ... & Grandoch, M. (2021). Endothelial hyaluronan synthase 3 augments postischemic arteriogenesis through CD44/eNOS signaling. Arteriosclerosis, thrombosis, and vascular biology, 41(10), 2551-2562.

Hundhausen, C., Schneckmann, R., Ostendorf, Y., Rimpler, J., von Glinski, A., Kohlmorgen, C., ... & Grandoch, M. (2021). Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease. Matrix Biology, 102, 20-36.

Lee, W. J., Chen, L. C., Lin, J. H., Cheng, T. C., Kuo, C. C., Wu, C. H., ... & Ho, Y. S. (2019). Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy. Cancer Medicine, 8(10), 4821-4835.

Homann, S., Grandoch, M., Kiene, L. S., Podsvyadek, Y., Feldmann, K., Rabausch, B., ... & Fischer, J. W. (2018). Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression. Matrix Biology, 66, 67-80.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Has3 ELISA Kit (CAT#: V2LY-0626-LY1492)

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Mouse Has3 ELISA Kit (CAT#: V2LY-0626-LY1492)

Mouse Anti-HAS3 Recombinant Antibody (CBFYH-0713) (CAT#: CBMAB-H1602-FY)

Mouse Anti-HAS3 Recombinant Antibody (CBT2969) (CAT#: V2LY-0625-LY2771)

Isotype control

For research use only. Not intended for any clinical use.

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