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Mouse Anti-HK3 (AA 1-923) Recombinant Antibody (CBFYH-1239) (CBMAB-H2211-FY)

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Basic Information

Host Animal
Mouse
Clone
CBFYH-1239
Application
ELISA, IHC-P, WB
Immunogen
Recombinant human Hexokinase 3 purified from E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.1% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-923
More Infomation

Target

Full Name
Hexokinase 3
Introduction
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate.
Entrez Gene ID
3101
UniProt ID
P52790
Alternative Names
Hexokinase 3; Hexokinase 3 (White Cell); Hexokinase Type III; EC 2.7.1.1; HK III; ATP:D-Hexose 6-Phosphotransferase
Function
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435).

Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435).
Biological Process
Canonical glycolysis Source: Reactome
Cellular glucose homeostasis Source: GO_Central
Fructose 6-phosphate metabolic process Source: UniProtKB
Glucose 6-phosphate metabolic process Source: UniProtKB
Glycolytic process Source: GO_Central
Cellular Location
Cytosol; Extracellular region; Mitochondrion; Ficolin-1-rich granule lumen; Secretory granule lumen

Li, T., Gu, Y., Xu, B., Kuca, K., Zhang, J., & Wu, W. (2023). CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure. Molecular Cancer, 22(1), 1-14.

Seiler, K., Humbert, M., Minder, P., Mashimo, I., Schläfli, A. M., Krauer, D., ... & Torbett, B. E. (2022). Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions. Cell death & disease, 13(5), 448.

van der Kooij, M. A., Rojas-Charry, L., Givehchi, M., Wolf, C., Bueno, D., Arndt, S., ... & Methner, A. (2022). Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels. Journal of Molecular Medicine, 100(10), 1441-1453.

Cai, T., Du, P., Suo, L., Jiang, X., Qin, Q., Song, R., ... & Zhang, J. A. (2022). High iodine promotes autoimmune thyroid disease by activating hexokinase 3 and inducing polarization of macrophages towards M1. Frontiers in Immunology, 13, 1009932.

Seiler, K., Tschan, M. P., Kalbermatter, C., Muralt, T., Rao, T. N., & Torbett, B. E. (2022). Non-Glycolytic Role of the Myeloid Hexokinase 3 (HK3) in Therapy Responses of Myeloid Malignancies. Blood, 140(Supplement 1), 5883-5883.

Xu, W., Liu, W. R., Xu, Y., Tian, X., Anwaier, A., Su, J. Q., ... & Ye, D. W. (2021). Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment. International journal of biological sciences, 17(9), 2205.

Tuo, Z., Zheng, X., Zong, Y., Li, J., Zou, C., Lv, Y., & Liu, J. (2020). HK3 is correlated with immune infiltrates and predicts response to immunotherapy in non‐small cell lung cancer. Clinical and translational medicine, 10(1), 319-330.

Lin, Y. H., Wu, Y., Wang, Y., Yao, Z. F., Tang, J., Wang, R., ... & He-Zuo, L. Ř. (2018). Spatio-temporal expression of Hexokinase-3 in the injured female rat spinal cords. Neurochemistry international, 113, 23-33.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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