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Mouse Anti-HK3 Recombinant Antibody (CBFYH-3583) (CBMAB-H4136-FY)

This product is mouse antibody that recognizes HK3. The antibody CBFYH-3583 can be used for immunoassay techniques such as: IHC.
See all HK3 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYH-3583
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Rat Type III hexokinase
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Hexokinase 3
Introduction
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate.
Entrez Gene ID
25060
UniProt ID
P27926
Alternative Names
RNU73859
Function
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:8717435).

Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:8717435).
Biological Process
Canonical glycolysis Source: Reactome
Cellular glucose homeostasis Source: GO_Central
Fructose 6-phosphate metabolic process Source: UniProtKB
Glucose 6-phosphate metabolic process Source: UniProtKB
Glycolytic process Source: GO_Central
Cellular Location
Cytosol; Extracellular region; Mitochondrion; Ficolin-1-rich granule lumen; Secretory granule lumen

Li, T., Gu, Y., Xu, B., Kuca, K., Zhang, J., & Wu, W. (2023). CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure. Molecular Cancer, 22(1), 1-14.

Seiler, K., Humbert, M., Minder, P., Mashimo, I., Schläfli, A. M., Krauer, D., ... & Torbett, B. E. (2022). Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions. Cell death & disease, 13(5), 448.

van der Kooij, M. A., Rojas-Charry, L., Givehchi, M., Wolf, C., Bueno, D., Arndt, S., ... & Methner, A. (2022). Chronic social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels. Journal of Molecular Medicine, 100(10), 1441-1453.

Cai, T., Du, P., Suo, L., Jiang, X., Qin, Q., Song, R., ... & Zhang, J. A. (2022). High iodine promotes autoimmune thyroid disease by activating hexokinase 3 and inducing polarization of macrophages towards M1. Frontiers in Immunology, 13, 1009932.

Seiler, K., Tschan, M. P., Kalbermatter, C., Muralt, T., Rao, T. N., & Torbett, B. E. (2022). Non-Glycolytic Role of the Myeloid Hexokinase 3 (HK3) in Therapy Responses of Myeloid Malignancies. Blood, 140(Supplement 1), 5883-5883.

Xu, W., Liu, W. R., Xu, Y., Tian, X., Anwaier, A., Su, J. Q., ... & Ye, D. W. (2021). Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment. International journal of biological sciences, 17(9), 2205.

Tuo, Z., Zheng, X., Zong, Y., Li, J., Zou, C., Lv, Y., & Liu, J. (2020). HK3 is correlated with immune infiltrates and predicts response to immunotherapy in non‐small cell lung cancer. Clinical and translational medicine, 10(1), 319-330.

Lin, Y. H., Wu, Y., Wang, Y., Yao, Z. F., Tang, J., Wang, R., ... & He-Zuo, L. Ř. (2018). Spatio-temporal expression of Hexokinase-3 in the injured female rat spinal cords. Neurochemistry international, 113, 23-33.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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