Rabbit Anti-HLX Recombinant Antibody (EG1521) (CBMAB-EN1819-LY)

The product is antibody recognizes HLX1. The antibody EG1521 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000.
See all HLX antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG1521

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human HLX1.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

H2.0 like homeobox

Entrez Gene ID

Human	3142
Mouse	15284
Rat	364069

UniProt ID

Human	Q14774
Mouse	Q61670
Rat	A0JPN1

Alternative Names

HB24; HLX1

Function

Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).

Biological Process

Cell differentiation Source: UniProtKB-KW
Embryonic digestive tract morphogenesis Source: Ensembl
Enteric nervous system development Source: Ensembl
Liver development Source: Ensembl
Multicellular organism development Source: ProtInc
Negative regulation of T-helper 2 cell differentiation Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of organ growth Source: Ensembl
Positive regulation of T-helper 1 cell differentiation Source: Ensembl
Skeletal muscle tissue development Source: Ensembl

Cellular Location

Nucleus

References

Zhu, X. Y., Guo, Q. Y., Zhu, M., Chen, B. G., Wang, L. Y., Zhang, D. Q., ... & Luo, W. D. (2020). HLX affects cell cycle and proliferation in AML cells via the JAK/STAT signaling pathway. Oncology Letters, 20(2), 1888-1896.

Piragyte, I., Clapes, T., Polyzou, A., Klein Geltink, R. I., Lefkopoulos, S., Yin, N., ... & Trompouki, E. (2018). A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature communications, 9(1), 3090.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-HLX (AA 176-279) Recombinant Antibody (CBFYH-1486)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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