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Rabbit Anti-HMMR Recombinant Antibody (EG1526) (CBMAB-EN1825-LY)

The product is antibody recognizes HMMR. The antibody EG1526 immunoassay techniques such as: WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000.
See all HMMR antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1526
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human HMMR.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
hyaluronan mediated motility receptor
Introduction
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Entrez Gene ID
Human3161
Mouse15366
Rat25460
UniProt ID
HumanO75330
MouseQ00547
RatP97779
Alternative Names
CD168; IHABP; RHAMM
Function
Receptor for hyaluronic acid (HA) (By similarity).

Involved in cell motility (By similarity).

When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 oCcurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).
Biological Process
Cytoplasm; Spindle; Cell surface

Tarullo, S. E., He, Y., Daughters, C., Knutson, T. P., Henzler, C. M., Price, M. A., ... & Nelson, A. C. (2023). Receptor for hyaluronan‐mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients. The Journal of Pathology.

Mei, L. (2022). Hyaluronan mediated motility receptor regulates daughter cell size control pathways during mitosis (Doctoral dissertation, University of British Columbia).

Sun, H., Ma, L., & Chen, J. (2021). Hyaluronan-mediated motility receptor expression functions as a prognostic biomarker in uterine carcinosarcoma based on bioinformatics analysis. Journal of International Medical Research, 49(6), 03000605211021043.

Tang, Y. P., Yin, Y. X., Xie, M. Z., Liang, X. Q., Li, J. L., Li, K. Z., & Hu, B. L. (2021). Systematic analysis of the clinical significance of hyaluronan-mediated motility receptor in colorectal cancer. Frontiers in Molecular Biosciences, 8, 733271.

Lu, T., Zheng, Y., Gong, X., Lv, Q., Chen, J., Tu, Z., ... & Li, J. (2021). High expression of hyaluronan-mediated motility receptor predicts adverse outcomes: a potential therapeutic target for head and neck squamous cell carcinoma. Frontiers in Oncology, 11, 608842.

Kang, H. G., Kim, W. J., Kang, H. G., Chun, K. H., & Kim, S. J. (2020). Galectin-3 interacts with C/EBPβ and upregulates hyaluronan-mediated motility receptor expression in gastric cancer. Molecular Cancer Research, 18(3), 403-413.

He, Z., Mei, L., Connell, M., & Maxwell, C. A. (2020). Hyaluronan mediated motility receptor (HMMR) encodes an evolutionarily conserved homeostasis, mitosis, and meiosis regulator rather than a hyaluronan receptor. Cells, 9(4), 819.

Ye, S., Liu, Y., Fuller, A. M., Katti, R., Ciotti, G. E., Chor, S., ... & Eisinger-Mathason, T. K. (2020). TGFβ and hippo pathways cooperate to enhance sarcomagenesis and metastasis through the hyaluronan-mediated motility receptor (HMMR). Molecular Cancer Research, 18(4), 560-573.

He, F., Zu, D., Lan, C., Niu, J., & Nie, X. (2020). hsa‑microRNA‑411‑5p regulates proliferation, migration and invasion by targeting the hyaluronan mediated motility receptor in ovarian cancer. Experimental and Therapeutic Medicine, 20(3), 1899-1906.

Zhang, H., Ren, L., Ding, Y., Li, F., Chen, X., Ouyang, Y., ... & Zhang, D. (2019). Hyaluronan‐mediated motility receptor confers resistance to chemotherapy via TGFβ/Smad2‐induced epithelial‐mesenchymal transition in gastric cancer. The FASEB Journal, 33(5), 6365-6377.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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