Human HMMR ELISA Kit (V2LY-0626-LY3658)

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Tested Data
Request for COA
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Basic Information

Sensitivity
0.024 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
84.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
hyaluronan mediated motility receptor
Function
Receptor for hyaluronic acid (HA) (By similarity).

Involved in cell motility (By similarity).

When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 oCcurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).
Biological Process
Cytoplasm; Spindle; Cell surface

Tarullo, S. E., He, Y., Daughters, C., Knutson, T. P., Henzler, C. M., Price, M. A., ... & Nelson, A. C. (2023). Receptor for hyaluronan‐mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients. The Journal of Pathology.

Mei, L. (2022). Hyaluronan mediated motility receptor regulates daughter cell size control pathways during mitosis (Doctoral dissertation, University of British Columbia).

Sun, H., Ma, L., & Chen, J. (2021). Hyaluronan-mediated motility receptor expression functions as a prognostic biomarker in uterine carcinosarcoma based on bioinformatics analysis. Journal of International Medical Research, 49(6), 03000605211021043.

Tang, Y. P., Yin, Y. X., Xie, M. Z., Liang, X. Q., Li, J. L., Li, K. Z., & Hu, B. L. (2021). Systematic analysis of the clinical significance of hyaluronan-mediated motility receptor in colorectal cancer. Frontiers in Molecular Biosciences, 8, 733271.

Lu, T., Zheng, Y., Gong, X., Lv, Q., Chen, J., Tu, Z., ... & Li, J. (2021). High expression of hyaluronan-mediated motility receptor predicts adverse outcomes: a potential therapeutic target for head and neck squamous cell carcinoma. Frontiers in Oncology, 11, 608842.

Kang, H. G., Kim, W. J., Kang, H. G., Chun, K. H., & Kim, S. J. (2020). Galectin-3 interacts with C/EBPβ and upregulates hyaluronan-mediated motility receptor expression in gastric cancer. Molecular Cancer Research, 18(3), 403-413.

He, Z., Mei, L., Connell, M., & Maxwell, C. A. (2020). Hyaluronan mediated motility receptor (HMMR) encodes an evolutionarily conserved homeostasis, mitosis, and meiosis regulator rather than a hyaluronan receptor. Cells, 9(4), 819.

Ye, S., Liu, Y., Fuller, A. M., Katti, R., Ciotti, G. E., Chor, S., ... & Eisinger-Mathason, T. K. (2020). TGFβ and hippo pathways cooperate to enhance sarcomagenesis and metastasis through the hyaluronan-mediated motility receptor (HMMR). Molecular Cancer Research, 18(4), 560-573.

He, F., Zu, D., Lan, C., Niu, J., & Nie, X. (2020). hsa‑microRNA‑411‑5p regulates proliferation, migration and invasion by targeting the hyaluronan mediated motility receptor in ovarian cancer. Experimental and Therapeutic Medicine, 20(3), 1899-1906.

Zhang, H., Ren, L., Ding, Y., Li, F., Chen, X., Ouyang, Y., ... & Zhang, D. (2019). Hyaluronan‐mediated motility receptor confers resistance to chemotherapy via TGFβ/Smad2‐induced epithelial‐mesenchymal transition in gastric cancer. The FASEB Journal, 33(5), 6365-6377.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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