Mouse Anti-HMMR Recombinant Antibody (2D6) (CBMAB-C4914-LY)

Name: Mouse Anti-HMMR Recombinant Antibody (2D6)
SKU: CBMAB-C4914-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2D6

Application

IHC-P, IHC-F, FC, ICC/IF

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

hyaluronan mediated motility receptor

Introduction

The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]

Entrez Gene ID

3161

UniProt ID

O75330

Alternative Names

Hyaluronan Mediated Motility Receptor; Intracellular Hyaluronic Acid-Binding Protein; Receptor For Hyaluronan-Mediated Motility; IHABP; RHAMM; Hyaluronan-Mediated Motility Receptor (RHAMM); Hyaluronan-Mediated Motility Receptor; CD168 Antigen; CD168;

Function

Receptor for hyaluronic acid (HA) (By similarity).

Involved in cell motility (By similarity).

When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 ^oCcurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis (By similarity).

Biological Process

Cytoplasm; Spindle; Cell surface

Tarullo, S. E., He, Y., Daughters, C., Knutson, T. P., Henzler, C. M., Price, M. A., ... & Nelson, A. C. (2023). Receptor for hyaluronan‐mediated motility (RHAMM) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patients. The Journal of Pathology.

Mei, L. (2022). Hyaluronan mediated motility receptor regulates daughter cell size control pathways during mitosis (Doctoral dissertation, University of British Columbia).

Sun, H., Ma, L., & Chen, J. (2021). Hyaluronan-mediated motility receptor expression functions as a prognostic biomarker in uterine carcinosarcoma based on bioinformatics analysis. Journal of International Medical Research, 49(6), 03000605211021043.

Tang, Y. P., Yin, Y. X., Xie, M. Z., Liang, X. Q., Li, J. L., Li, K. Z., & Hu, B. L. (2021). Systematic analysis of the clinical significance of hyaluronan-mediated motility receptor in colorectal cancer. Frontiers in Molecular Biosciences, 8, 733271.

Lu, T., Zheng, Y., Gong, X., Lv, Q., Chen, J., Tu, Z., ... & Li, J. (2021). High expression of hyaluronan-mediated motility receptor predicts adverse outcomes: a potential therapeutic target for head and neck squamous cell carcinoma. Frontiers in Oncology, 11, 608842.

Kang, H. G., Kim, W. J., Kang, H. G., Chun, K. H., & Kim, S. J. (2020). Galectin-3 interacts with C/EBPβ and upregulates hyaluronan-mediated motility receptor expression in gastric cancer. Molecular Cancer Research, 18(3), 403-413.

He, Z., Mei, L., Connell, M., & Maxwell, C. A. (2020). Hyaluronan mediated motility receptor (HMMR) encodes an evolutionarily conserved homeostasis, mitosis, and meiosis regulator rather than a hyaluronan receptor. Cells, 9(4), 819.

Ye, S., Liu, Y., Fuller, A. M., Katti, R., Ciotti, G. E., Chor, S., ... & Eisinger-Mathason, T. K. (2020). TGFβ and hippo pathways cooperate to enhance sarcomagenesis and metastasis through the hyaluronan-mediated motility receptor (HMMR). Molecular Cancer Research, 18(4), 560-573.

He, F., Zu, D., Lan, C., Niu, J., & Nie, X. (2020). hsa‑microRNA‑411‑5p regulates proliferation, migration and invasion by targeting the hyaluronan mediated motility receptor in ovarian cancer. Experimental and Therapeutic Medicine, 20(3), 1899-1906.

Zhang, H., Ren, L., Ding, Y., Li, F., Chen, X., Ouyang, Y., ... & Zhang, D. (2019). Hyaluronan‐mediated motility receptor confers resistance to chemotherapy via TGFβ/Smad2‐induced epithelial‐mesenchymal transition in gastric cancer. The FASEB Journal, 33(5), 6365-6377.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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