Mouse Anti-HOXC4 Recombinant Antibody (1E9) (CBMAB-A4060-LY)

Name: Mouse Anti-HOXC4 Recombinant Antibody (1E9)
SKU: CBMAB-A4060-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E9

Application

WB, ELISA

Immunogen

HOXC4 (NP_705897, 160 a.a. ~ 264 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Homeobox C4

Introduction

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq]

Entrez Gene ID

3221

UniProt ID

P09017

Alternative Names

HOX3; HOX3E; cp19

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Cartilage development Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Brockmeyer, D. L., Cheshier, S. H., Stevens, J., Facelli, J. C., Rowe, K., Heiss, J. D., ... & Cannon-Albright, L. A. (2023). A likely HOXC4 predisposition variant for Chiari malformations. Journal of Neurosurgery, 139(1), 266-274.

Chen, K., Zhang, B., & Sun, Z. (2022). Histone H3K27 Demethylase KDM6A Regulates Cardiac Aging viaInduction of HoxC4 mediated ER Stress. The FASEB Journal, 36.

Liu, L., Yu, T., Jin, Y., Mai, W., Zhou, J., & Zhao, C. (2021). MicroRNA-15a carried by mesenchymal stem cell-derived extracellular vesicles inhibits the immune evasion of colorectal cancer cells by regulating the KDM4B/HOXC4/PD-L1 axis. Frontiers in cell and developmental biology, 9, 629893.

Wu, S., Chen, H., Zuo, L., Jiang, H., & Yan, H. (2020). Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4. American Journal of Physiology-Cell Physiology, 318(5), C903-C912.

Luo, Z., & Farnham, P. J. (2020). Genome-wide analysis of HOXC4 and HOXC6 regulated genes and binding sites in prostate cancer cells. PLoS One, 15(2), e0228590.

Zeng, J., Sun, W., Chang, J., Yi, D., Zhu, L., Zhang, Y., ... & Ma, F. (2020). HOXC4 up-regulates NF-κB signaling and promotes the cell proliferation to drive development of human hematopoiesis, especially CD43+ cells. Blood Science, 2(04), 117-128.

Li, Y., Li, Y. H., Zhou, X., Wu, B., Chen, J. P., Wang, Z. K., ... & Li, R. S. (2018). DNA hydroxymethylation rate in the AChE and HoxC4 promoter associated with human sperm quality. Andrologia, 50(4), e12963.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

HOXC4 Matched Antibody Pair (569) (CAT#: APMAB-569LY)

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Mouse Anti-HOXC4 Recombinant Antibody (2D6) (CAT#: CBMAB-A4061-LY)

HOXC4 Matched Antibody Pair (569) (CAT#: APMAB-569LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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