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Mouse Anti-HOXC4 Recombinant Antibody (1E9) (CBMAB-A4060-LY)

The product is antibody recognizes HOXC4. The antibody 1E9 immunoassay techniques such as: WB, ELISA.
See all HOXC4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXC4 (NP_705897, 160 a.a. ~ 264 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Homeobox C4
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq]
Entrez Gene ID
3221
UniProt ID
P09017
Alternative Names
HOX3; HOX3E; cp19
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Cartilage development Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Brockmeyer, D. L., Cheshier, S. H., Stevens, J., Facelli, J. C., Rowe, K., Heiss, J. D., ... & Cannon-Albright, L. A. (2023). A likely HOXC4 predisposition variant for Chiari malformations. Journal of Neurosurgery, 139(1), 266-274.

Chen, K., Zhang, B., & Sun, Z. (2022). Histone H3K27 Demethylase KDM6A Regulates Cardiac Aging viaInduction of HoxC4 mediated ER Stress. The FASEB Journal, 36.

Liu, L., Yu, T., Jin, Y., Mai, W., Zhou, J., & Zhao, C. (2021). MicroRNA-15a carried by mesenchymal stem cell-derived extracellular vesicles inhibits the immune evasion of colorectal cancer cells by regulating the KDM4B/HOXC4/PD-L1 axis. Frontiers in cell and developmental biology, 9, 629893.

Wu, S., Chen, H., Zuo, L., Jiang, H., & Yan, H. (2020). Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4. American Journal of Physiology-Cell Physiology, 318(5), C903-C912.

Luo, Z., & Farnham, P. J. (2020). Genome-wide analysis of HOXC4 and HOXC6 regulated genes and binding sites in prostate cancer cells. PLoS One, 15(2), e0228590.

Zeng, J., Sun, W., Chang, J., Yi, D., Zhu, L., Zhang, Y., ... & Ma, F. (2020). HOXC4 up-regulates NF-κB signaling and promotes the cell proliferation to drive development of human hematopoiesis, especially CD43+ cells. Blood Science, 2(04), 117-128.

Li, Y., Li, Y. H., Zhou, X., Wu, B., Chen, J. P., Wang, Z. K., ... & Li, R. S. (2018). DNA hydroxymethylation rate in the AChE and HoxC4 promoter associated with human sperm quality. Andrologia, 50(4), e12963.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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