HOXC4
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]
                Full Name
                    Homeobox C4
                Function
                    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
                Biological Process
                    Anterior/posterior pattern specification Source: GO_Central
Cartilage development Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
                Cartilage development Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
                    Nucleus
                
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                    Anti-HOXC4 antibodies
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        Target: HOXC4
                
                Specificity: Human
                
            Target: HOXC4
                
                Host: Mouse
                
                Antibody Isotype: IgG1, κ
                
                Specificity: Human
                
                Clone: 2D6
                
                Application*: WB, E
                
            Target: HOXC4
                
                Host: Mouse
                
                Antibody Isotype: IgG2a, κ
                
                Specificity: Human
                
                Clone: 1E9
                
                Application*: WB, E
                
            Target: HOXC4
                
                Host: Mouse
                
                Antibody Isotype: IgG1, κ
                
                Specificity: Human
                
                Clone: CBFYH-1817
                
                Application*: IF, WB
                
            Target: HOXC4
                
                Host: Mouse
                
                Antibody Isotype: IgG2a
                
                Specificity: Human
                
                Clone: CBFYH-1814
                
                Application*: E, WB
                
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For Research Use Only. Not For Clinical Use.
                    (P): Predicted
* Abbreviations 
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
 
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