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HOXC4 Matched Antibody Pair (569) (APMAB-569LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-HOXC4 polyclonal antibody, 100 ug
Detection Antibody
Anti-HOXC4 Mouse monoclonal, IgG1 antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. [provided by RefSeq, Jul 2008]
Alternative Names
Homeobox C4; Homeobox Protein Hox-3E; Homeobox Protein CP19; HOX3E; Homeobox Protein Hox-C4; Homeo Box C4; Homeo Box 3E; HOX3; Cp19;
Entrez Gene ID
3221
UniProt ID
P09017
More Infomation

Brockmeyer, D. L., Cheshier, S. H., Stevens, J., Facelli, J. C., Rowe, K., Heiss, J. D., ... & Cannon-Albright, L. A. (2023). A likely HOXC4 predisposition variant for Chiari malformations. Journal of Neurosurgery, 139(1), 266-274.

Chen, K., Zhang, B., & Sun, Z. (2022). Histone H3K27 Demethylase KDM6A Regulates Cardiac Aging viaInduction of HoxC4 mediated ER Stress. The FASEB Journal, 36.

Liu, L., Yu, T., Jin, Y., Mai, W., Zhou, J., & Zhao, C. (2021). MicroRNA-15a carried by mesenchymal stem cell-derived extracellular vesicles inhibits the immune evasion of colorectal cancer cells by regulating the KDM4B/HOXC4/PD-L1 axis. Frontiers in cell and developmental biology, 9, 629893.

Wu, S., Chen, H., Zuo, L., Jiang, H., & Yan, H. (2020). Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4. American Journal of Physiology-Cell Physiology, 318(5), C903-C912.

Luo, Z., & Farnham, P. J. (2020). Genome-wide analysis of HOXC4 and HOXC6 regulated genes and binding sites in prostate cancer cells. PLoS One, 15(2), e0228590.

Zeng, J., Sun, W., Chang, J., Yi, D., Zhu, L., Zhang, Y., ... & Ma, F. (2020). HOXC4 up-regulates NF-κB signaling and promotes the cell proliferation to drive development of human hematopoiesis, especially CD43+ cells. Blood Science, 2(04), 117-128.

Li, Y., Li, Y. H., Zhou, X., Wu, B., Chen, J. P., Wang, Z. K., ... & Li, R. S. (2018). DNA hydroxymethylation rate in the AChE and HoxC4 promoter associated with human sperm quality. Andrologia, 50(4), e12963.

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For research use only. Not intended for any clinical use.

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