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Mouse Anti-HOXD8 Recombinant Antibody (5E11) (CBMAB-A4080-LY)

The product is antibody recognizes HOXD8. The antibody 5E11 immunoassay techniques such as: WB, ELISA.
See all HOXD8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5E11
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HOXD8 (NP_062458, 126 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Homeobox D8
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. [provided by RefSeq]
Entrez Gene ID
3234
UniProt ID
P13378
Alternative Names
HOX4; HOX4E; HOX5.4
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior axis specification, embryo Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal system morphogenesis Source: Ensembl
Cellular Location
Nucleus

Loi, E., Zavattari, C., Tommasi, A., Moi, L., Canale, M., Po, A., ... & Zavattari, P. (2022). HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples. British Journal of Cancer, 126(12), 1783-1794.

Liu, J., Li, J., Su, Y., Ma, Z., Yu, S., & Meng, X. (2022). CircTMEM59 Serves as miR-410-3p sponge to inhibit the proliferation and metastasis of colorectal cancer by regulating HOXD8. Biochemical Genetics, 60(6), 2399-2415.

Ye, W., Huang, Y., Zhu, G., Yan, A., Liu, Y., Xiao, H., & Mei, H. (2022). miR-30a inhibits the osteogenic differentiation of the tibia-derived MSCs in congenital pseudarthrosis via targeting HOXD8. Regenerative Therapy, 21, 477-485.

Wen, X., Chen, Y., & Fang, X. (2021). Overexpression of HOXD8 inhibits the proliferation, migration and invasion of breast cancer cells by downregulating ILP2 expression. Experimental and Therapeutic Medicine, 22(3), 1-9.

Zhang, Y., Yu, Y., Su, X., & Lu, Y. (2021). HOXD8 inhibits the proliferation and migration of triple-negative breast cancer cells and induces apoptosis in them through regulation of AKT/mTOR pathway. Reproductive biology, 21(4), 100544.

Yao, L., Ye, P. C., Tan, W., Luo, Y. J., Xiang, W. P., Liu, Z. L., ... & Xiao, J. W. (2020). Decreased expression of the long non-coding RNA HOXD-AS2 promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway. World Journal of Gastrointestinal Oncology, 12(11), 1237.

Meng, L., Xing, Z., Guo, Z., & Liu, Z. (2020). LINC01106 post-transcriptionally regulates ELK3 and HOXD8 to promote bladder cancer progression. Cell death & disease, 11(12), 1063.

Zhu, W., Wang, J. P., Meng, Q. Z., Zhu, F., & Hao, X. F. (2020). MiR-142-5p reverses the resistance to gefitinib through targeting HOXD8 in lung cancer cells. European Review for Medical & Pharmacological Sciences, 24(8).

Sun, S., Wang, N., Sun, Z., Wang, X., & Cui, H. (2019). MiR-5692a promotes proliferation and inhibits apoptosis by targeting HOXD8 in hepatocellular carcinoma. J BUON, 24(1), 178-186.

Sun, P., Song, Y., Liu, D., Liu, G., Mao, X., Dong, B., ... & Sehouli, J. (2018). Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer. Scientific reports, 8(1), 13483.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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