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HOXD8 Matched Antibody Pair (572) (APMAB-572LY)

This antibody pair set can be used for detecting and quantifying protein level of human HOXD8.
See all HOXD8 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-HOXD8 polyclonal antibody, 100 ug
Detection Antibody
Anti-HOXD8 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Alternative Names
Homeobox D8; Homeobox Protein Hox-5.4; Homeobox Protein Hox-4E; Homeo Box D8; HOX4E; Homeobox Protein Hox-D8;
Entrez Gene ID
3234
UniProt ID
P13378

Loi, E., Zavattari, C., Tommasi, A., Moi, L., Canale, M., Po, A., ... & Zavattari, P. (2022). HOXD8 hypermethylation as a fully sensitive and specific biomarker for biliary tract cancer detectable in tissue and bile samples. British Journal of Cancer, 126(12), 1783-1794.

Liu, J., Li, J., Su, Y., Ma, Z., Yu, S., & Meng, X. (2022). CircTMEM59 Serves as miR-410-3p sponge to inhibit the proliferation and metastasis of colorectal cancer by regulating HOXD8. Biochemical Genetics, 60(6), 2399-2415.

Ye, W., Huang, Y., Zhu, G., Yan, A., Liu, Y., Xiao, H., & Mei, H. (2022). miR-30a inhibits the osteogenic differentiation of the tibia-derived MSCs in congenital pseudarthrosis via targeting HOXD8. Regenerative Therapy, 21, 477-485.

Wen, X., Chen, Y., & Fang, X. (2021). Overexpression of HOXD8 inhibits the proliferation, migration and invasion of breast cancer cells by downregulating ILP2 expression. Experimental and Therapeutic Medicine, 22(3), 1-9.

Zhang, Y., Yu, Y., Su, X., & Lu, Y. (2021). HOXD8 inhibits the proliferation and migration of triple-negative breast cancer cells and induces apoptosis in them through regulation of AKT/mTOR pathway. Reproductive biology, 21(4), 100544.

Yao, L., Ye, P. C., Tan, W., Luo, Y. J., Xiang, W. P., Liu, Z. L., ... & Xiao, J. W. (2020). Decreased expression of the long non-coding RNA HOXD-AS2 promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway. World Journal of Gastrointestinal Oncology, 12(11), 1237.

Meng, L., Xing, Z., Guo, Z., & Liu, Z. (2020). LINC01106 post-transcriptionally regulates ELK3 and HOXD8 to promote bladder cancer progression. Cell death & disease, 11(12), 1063.

Zhu, W., Wang, J. P., Meng, Q. Z., Zhu, F., & Hao, X. F. (2020). MiR-142-5p reverses the resistance to gefitinib through targeting HOXD8 in lung cancer cells. European Review for Medical & Pharmacological Sciences, 24(8).

Sun, S., Wang, N., Sun, Z., Wang, X., & Cui, H. (2019). MiR-5692a promotes proliferation and inhibits apoptosis by targeting HOXD8 in hepatocellular carcinoma. J BUON, 24(1), 178-186.

Sun, P., Song, Y., Liu, D., Liu, G., Mao, X., Dong, B., ... & Sehouli, J. (2018). Potential role of the HOXD8 transcription factor in cisplatin resistance and tumour metastasis in advanced epithelial ovarian cancer. Scientific reports, 8(1), 13483.

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For research use only. Not intended for any clinical use.

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