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Mouse Anti-HTN1 Recombinant Antibody (A343) (CBMAB-AP3036LY)

The product is antibody recognizes HTN1. The antibody A343 immunoassay techniques such as: ICC, IHC, IP, WB.
See all HTN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A343
Antibody Isotype
IgG2b, κ
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Asp20~Asn57
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Histatin 1
Introduction
This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]
Entrez Gene ID
3346
UniProt ID
P15515
Alternative Names
Histatin 1; Histidine-Rich Protein 1; Post-PB Protein; HIS1; PPB; Histatin-1;
Function
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Biomineral tissue development Source: UniProtKB-KW
Defense response to bacterium Source: UniProtKB
Defense response to fungus Source: UniProtKB-KW
Killing of cells of other organism Source: UniProtKB
Cellular Location
Secreted
PTM
Depending on the authors, the form called histatin-2 is alternatively a proteolytic product, or the non-phosphorylated form of histatin-1.

Ma, D., Sun, W., Fu, C., Nazmi, K., Veerman, E. C., Jaspers, R. T., ... & Wu, G. (2022). GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and-activating properties of human salivary histatin 1. International Journal of Oral Science, 14(1), 42.

Son, K. N., Lee, H., Shah, D., Kalmodia, S., Miller, R. C., Ali, M., ... & Aakalu, V. K. (2021). Histatin‐1 is an endogenous ligand of the sigma‐2 receptor. The FEBS journal, 288(23), 6815-6827.

Dewi, N. K. A. F., Permatasari, N., & Sujuti, H. (2021). Effect of Histatin-1 Proteins to Fibroblasts Growth Factor-2 (FGF2) Concentrate and Fibroblasts Cell Migration on Human Gingival Fibroblast (HGF) Culture. Research Journal of Life Science, 8(2), 95-102.

Kalmodia, S., Son, K. N., Cao, D., Lee, B. S., Surenkhuu, B., Shah, D., ... & Aakalu, V. K. (2019). Presence of histatin-1 in human tears and association with aqueous deficient dry eye diagnosis: a preliminary study. Scientific reports, 9(1), 10304.

Huang, G. Q., Yi, G. G., Wu, L. W., Feng, S. F., Wu, W., Peng, L., ... & Lu, X. (2018). Protective effect of histatin 1 against ultraviolet‑induced damage to human corneal epithelial cells. Experimental and therapeutic medicine, 15(1), 679-684.

van Dijk, I. A., Veerman, E. C., Reits, E. A., Bolscher, J. G., & Stap, J. (2018). Salivary peptide histatin 1 mediated cell adhesion: a possible role in mesenchymal-epithelial transition and in pathologies. Biological chemistry, 399(12), 1409-1419.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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