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Rabbit Anti-IFIT1 Recombinant Antibody (CBYY-I1659) (CBMAB-I2829-YY)

This product is Rabbit antibody that recognizes IFIT1 . The antibody CBYY-I1659 can be used for immunoassay techniques such as: IP, WB
See all IFIT1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYY-I1659
Application
IP, WB

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10 mM sodium HEPES, pH 7.5, 100 ug/ml BSA, 150 mM NaCl, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interferon Induced Protein With Tetratricopeptide Repeats 1
Introduction
This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
Entrez Gene ID
3434
UniProt ID
P09914
Alternative Names
Interferon Induced Protein With Tetratricopeptide Repeats 1
Function
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
Biological Process
Antiviral innate immune response Source: ARUK-UCL
Cellular response to exogenous dsRNA Source: BHF-UCL
Cellular response to type I interferon Source: BHF-UCL
Defense response to virus Source: GO_Central
Intracellular transport of viral protein in host cell Source: BHF-UCL
Negative regulation of helicase activity Source: BHF-UCL
Negative regulation of protein binding Source: BHF-UCL
Negative regulation of viral genome replication Source: UniProtKB
Positive regulation of viral genome replication Source: BHF-UCL
Regulation of defense response to virus Source: InterPro
Response to virus Source: BHF-UCL
Cellular Location
Cytoplasm
PTM
Phosphorylated.
ISGylated.

Gao, Y., Zou, T., Xu, P., Wang, Y., Jiang, Y., Chen, Y. X., ... & Fang, J. Y. (2023). Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer. Neoplasia, 35, 100850.

Schindewolf, C., Lokugamage, K., Vu, M. N., Johnson, B. A., Scharton, D., Plante, J. A., ... & Menachery, V. D. (2023). SARS-CoV-2 uses nonstructural protein 16 to evade restriction by IFIT1 and IFIT3. Journal of virology, 97(2), e01532-22.

Russ, A., Wittmann, S., Tsukamoto, Y., Herrmann, A., Deutschmann, J., Lagisquet, J., ... & Gramberg, T. (2022). Nsp16 shields SARS–CoV‐2 from efficient MDA5 sensing and IFIT1‐mediated restriction. EMBO reports, 23(12), e55648.

Zhang, M., Zhu, Y., Zhu, J., Xie, Y., Wu, R., Zhong, J., ... & Jiang, L. (2022). circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p. Cellular & Molecular Biology Letters, 27(1), 1-26.

Liu, G., Sun, J., Yang, Z. F., Zhou, C., Zhou, P. Y., Guan, R. Y., ... & Yi, Y. (2021). Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis. Cell death & disease, 12(3), 260.

Li, T. H., Zhao, B. B., Qin, C., Wang, Y. Y., Li, Z. R., Cao, H. T., ... & Wang, W. B. (2021). IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling. Cellular Oncology, 44(6), 1425-1437.

Pidugu, V. K., Wu, M. M., Yen, A. H., Pidugu, H. B., Chang, K. W., Liu, C. J., & Lee, T. C. (2019). IFIT1 and IFIT3 promote oral squamous cell carcinoma metastasis and contribute to the anti-tumor effect of gefitinib via enhancing p-EGFR recycling. Oncogene, 38(17), 3232-3247.

Johnson, B., VanBlargan, L. A., Xu, W., White, J. P., Shan, C., Shi, P. Y., ... & Amarasinghe, G. K. (2018). Human IFIT3 modulates IFIT1 RNA binding specificity and protein stability. Immunity, 48(3), 487-499.

Fleith, R. C., Mears, H. V., Leong, X. Y., Sanford, T. J., Emmott, E., Graham, S. C., ... & Sweeney, T. R. (2018). IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA. Nucleic acids research, 46(10), 5269-5285.

John, S. P., Sun, J., Carlson, R. J., Cao, B., Bradfield, C. J., Song, J., ... & Fraser, I. D. (2018). IFIT1 exerts opposing regulatory effects on the inflammatory and interferon gene programs in LPS-activated human macrophages. Cell reports, 25(1), 95-106.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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